PPP3CA anticorps (C-Term)

N° du produit ABIN3042493

Détail du produit anti-PPP3CA anticorps

Antigène: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Épitope: AA 488-521, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP3CA est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform(PPP3CA) detection. Tested with WB in Human.

Séquence: DAMPSDANLN SINKALTSET NGTDSNGSNS SNIQ

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform(PPP3CA) detection. Tested with WB in Human.
Gene Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Calcineurin A (488-521aa DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ), different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-PPP3CA (ABIN3042493)

Chu, Li, Gao, Wang, Han: "Buckwheat Rutin Inhibits AngII-induced Cardiomyocyte Hypertrophy via Blockade of CaN-dependent Signal Pathway." dans: Iranian journal of pharmaceutical research : IJPR, Vol. 13, Issue 4, pp. 1347-55, (2015) (PubMed).

Détails sur PPP3CA

Antigène: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Autre désignation: PPP3CA (PPP3CA Produits)

Synonymes: anticorps CALN, anticorps CALNA, anticorps CALNA1, anticorps CCN1, anticorps CNA1, anticorps PPP2B, anticorps 2900074D19Rik, anticorps AI841391, anticorps AW413465, anticorps CN, anticorps Caln, anticorps Calna, anticorps CnA, anticorps Calna1, anticorps calcineurin, anticorps caln, anticorps calna, anticorps calna1, anticorps ccn1, anticorps cna1, anticorps ppp2b, anticorps fj46e08, anticorps si:dkeyp-79c2.2, anticorps wu:fj46e08, anticorps ppp3ca, anticorps protein phosphatase 3 catalytic subunit alpha, anticorps protein phosphatase 3, catalytic subunit, alpha isoform, anticorps protein phosphatase 3, catalytic subunit, alpha isozyme, anticorps protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha), anticorps protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog, anticorps serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, anticorps PPP3CA, anticorps Ppp3ca, anticorps ppp3ca, anticorps ppp3ca.L, anticorps LOC100205420

Sujet: Calcineurin A is also known as PPP3CA. It is mapped to 4q24. Semsarian et al. (1999) and Musaro et al. (1999) independently showed that IGF1stimulates skeletal muscle hypertrophy and a switch to glycolytic metabolism by activating calcineurin A and inducing the nuclear translocation of transcription factor NFATC1. Semsarian et al. (1999) found that hypertrophy was suppressed by the calcineurin inhibitors cyclosporin A or FK506, but not by inhibitors of the MAP kinase or phosphatidylinositol-3-OH kinase pathways. Musaro et al. (1999) showed that expression of a dominant-negative calcineurin mutant also repressed myocyte differentiation and hypertrophy. Musaro et al. (1999) demonstrated that either IGF1 or activated calcineurin induces expression of transcription factor GATA2, which accumulates in a subset of myocyte nuclei, where it associates with calcineurin and a specific dephosphorylated isoform of NFATC1.

Synonyms: Alpha isoform formerly PPP2B antibody|Calcineurin A alpha antibody|Calcineurin A1 antibody|CalcineurinA antibody|Calmodulin dependent calcineurin A subunit alpha isoform antibody|Calmodulin-dependent calcineurin A subunit alpha isoform antibody|CALN antibody|CALNA 1 antibody|CALNA antibody|CALNA1 antibody|CAM PRP catalytic subunit antibody|CAM-PRP catalytic subunit antibody|CCN 1 antibody|CCN1 antibody|CNA 1 antibody|CNA alpha antibody|CNA antibody|CNA1 antibody|FLJ26613 antibody|MGC52248 antibody|PP2BA_HUMAN antibody|PPP2B antibody|PPP3CA antibody|Protein phosphatase 2B catalytic subunit antibody|Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody|Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA antibody|Protein phosphatase 3 catalytic subunit alpha isozyme antibody|Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody

ID gène: 5530

UniProt: Q08209

Pathways: Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling