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PINX1 anticorps (N-Term)

PINX1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3042502
  • Antigène Voir toutes PINX1 Anticorps
    PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))
    Épitope
    • 15
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 54-83, N-Term
    Reactivité
    • 38
    • 21
    • 19
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 35
    • 2
    • 1
    Lapin
    Clonalité
    • 37
    Polyclonal
    Conjugué
    • 20
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PINX1 est non-conjugé
    Application
    • 31
    • 14
    • 13
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for PIN2/TERF1-interacting telomerase inhibitor 1(PINX1) detection. Tested with WB in Human.
    Séquence
    DHIKVQVKNN HLGLGATINN EDNWIAHQDD
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for PIN2/TERF1-interacting telomerase inhibitor 1(PINX1) detection. Tested with WB in Human.
    Gene Name: PIN2/TERF1 interacting, telomerase inhibitor 1
    Protein Name: PIN2/TERF1-interacting telomerase inhibitor 1
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1 (54-83aa DHIKVQVKNNHLGLGATINNEDNWIAHQDD), different from the related mouse and rat sequences by three amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PINX1 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Antigène
    PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))
    Autre désignation
    PINX1 (PINX1 Produits)
    Synonymes
    anticorps PINX1, anticorps LPTL, anticorps LPTS, anticorps 2210403I16Rik, anticorps 2610028A01Rik, anticorps 67-11-3, anticorps AU024023, anticorps LPTS1, anticorps RGD1566025, anticorps PIN2/TERF1 interacting telomerase inhibitor 1, anticorps PIN2/TERF1 interacting, telomerase inhibitor 1, anticorps PINX1, anticorps Pinx1
    Sujet
    PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.

    Synonyms: 67-11-3 protein antibodyFLJ20565 antibody|Hepatocellular carcinoma-related putative tumor suppressor antibody|Liver-related putative tumor suppressor antibody|LPTL antibody|LPTS antibody|MGC8850 antibody|OTTHUMP00000224984 antibody|OTTHUMP00000224985 antibody| OTTHUMP00000224986 antibody|OTTHUMP00000225053 antibody|OTTHUMP00000225054 antibody|PIN2 interacting protein 1 antibody|Pin2-interacting protein X1 antibody|PIN2/TERF1-interacting telomerase inhibitor 1 antibody|PINX1 antibody|PINX1_HUMAN antibody|Protein 67-11-3 antibody|TRF1-interacting protein 1 antibody
    ID gène
    54984
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