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IL-8 anticorps (C-Term)

IL8 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3042619
  • Antigène Voir toutes IL-8 (IL8) Anticorps
    IL-8 (IL8) (Interleukin 8 (IL8))
    Épitope
    • 45
    • 21
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 77-95, C-Term
    Reactivité
    • 139
    • 22
    • 15
    • 13
    • 12
    • 12
    • 10
    • 9
    • 9
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    Humain
    Hôte
    • 119
    • 107
    • 7
    • 3
    • 3
    • 3
    • 1
    Lapin
    Clonalité
    • 135
    • 108
    Polyclonal
    Conjugué
    • 128
    • 50
    • 29
    • 9
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp IL-8 est non-conjugé
    Application
    • 158
    • 103
    • 78
    • 36
    • 35
    • 33
    • 16
    • 16
    • 16
    • 14
    • 10
    • 9
    • 9
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for Interleukin-8(CXCL8) detection. Tested with WB, IHC-P in Human.
    Séquence
    CLDPKENWVQ RVVEKFLKR
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Interleukin-8(CXCL8) detection. Tested with WB, IHC-P in Human.
    Gene Name: C-X-C motif chemokine ligand 8
    Protein Name: Interleukin-8(IL-8)
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of human IL8(77-95aa CLDPKENWVQRVVEKFLKR).
    Isotype
    IgG
    Top Product
    Discover our top product IL8 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Date de péremption
    12 months
  • Li, Lu, Sun, Zuo, Wang, Yan: "Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm." dans: PLoS ONE, Vol. 12, Issue 4, pp. e0174821, (2017) (PubMed).

    Yu, Lu, Li, Xiao, Xing, Li, Wu: "Role of S100A1 in hypoxia-induced inflammatory response in cardiomyocytes via TLR4/ROS/NF-?B pathway." dans: The Journal of pharmacy and pharmacology, Vol. 67, Issue 9, pp. 1240-50, (2015) (PubMed).

    Zhang, Xia, Han, Jiang, Rong, Song, Wang: "Cathelicidin-BF, a Novel Antimicrobial Peptide from Bungarus fasciatus, Attenuates Disease in a Dextran Sulfate Sodium Model of Colitis." dans: Molecular pharmaceutics, Vol. 12, Issue 5, pp. 1648-61, (2015) (PubMed).

    Xiao, Gang, Wang, Wang, Zhao, Xu, Liu: "Double-stranded RNA transcribed from vector-based oligodeoxynucleotide acts as transcription factor decoy." dans: Biochemical and biophysical research communications, Vol. 457, Issue 2, pp. 221-6, (2015) (PubMed).

    Ren, Li, Hu, Wang, Hu: "Melatonin regulates the rhythmic migration of neutrophils in live zebrafish." dans: Journal of pineal research, Vol. 58, Issue 4, pp. 452-60, (2015) (PubMed).

    Capsoni, Ongari, Lonati, Accetta, Gatti, Catania: "?-Melanocyte-stimulating-hormone (?-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines." dans: BMC musculoskeletal disorders, Vol. 16, pp. 154, (2015) (PubMed).

    Dong, Zhong, Lu, Li, Jiang, Mao: "Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-?B Pathway in HBE16 Airway Epithelial Cells." dans: Inflammation, Vol. 38, Issue 4, pp. 1493-501, (2015) (PubMed).

    Wang, Zhuo, Hu, Shen, Zhang, Chu: "CD147 deficiency blocks IL-8 secretion and inhibits lung cancer-induced osteoclastogenesis." dans: Biochemical and biophysical research communications, Vol. 458, Issue 2, pp. 268-73, (2015) (PubMed).

    Pei, Li, Zhan, Yu, Wei, Guan, Aydin, Elson, Zhou, He, Zhang: "Enhanced IMP3 Expression Activates NF-?B Pathway and Promotes Renal Cell Carcinoma Progression." dans: PLoS ONE, Vol. 10, Issue 4, pp. e0124338, (2015) (PubMed).

    Yu, Liu, Chen, Zeng: "Anti-inflammatory effect of Qingwen Baidu Decoction (?????) in sepsis rats." dans: Chinese journal of integrative medicine, Vol. 20, Issue 12, pp. 934-43, (2014) (PubMed).

    Li, Qian, Ju, Wang: "Upregulation of Toll-like receptor 2 expression in colorectal cancer infected by human cytomegalovirus." dans: Oncology letters, Vol. 9, Issue 1, pp. 365-370, (2014) (PubMed).

    Huang, Du, Fan, Lv, Qian, Zhang, Han, Chen, Wu, Jin: "The effect of proinflammatory cytokines on IL-17RA expression in NSCLC." dans: Medical oncology (Northwood, London, England), Vol. 31, Issue 9, pp. 144, (2014) (PubMed).

    Liu, Zhang, Xiao, Dai, Sun, Chen, Chen: "Three-dimensional collagen scaffold enhances the human adenoid cystic carcinoma cancer stem cell and epithelial-mesenchymal transition properties." dans: Journal of biomedical materials research. Part B, Applied biomaterials, Vol. 102, Issue 4, pp. 772-80, (2014) (PubMed).

    Hu, Yang, Zhang, Liu, Zhang, Lin, Huang, Wang, Zhang, Zhong, Shu: "TRIM38 inhibits TNF?- and IL-1?-triggered NF-?B activation by mediating lysosome-dependent degradation of TAB2/3." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 4, pp. 1509-14, (2014) (PubMed).

    Zhang, Feng, Liu, Zhang, Liang, Tang: "Roles of PI3K/Akt and c-Jun signaling pathways in human papillomavirus type 16 oncoprotein-induced HIF-1?, VEGF, and IL-8 expression and in vitro angiogenesis in non-small cell lung cancer cells." dans: PLoS ONE, Vol. 9, Issue 7, pp. e103440, (2014) (PubMed).

    Bao, Zhang, Lou, Xiao, Cheng, Zhou: "Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS." dans: Canadian journal of physiology and pharmacology, Vol. 92, Issue 4, pp. 299-306, (2014) (PubMed).

    Li, Yang, Yao, Li, Tian, Li, Jiang, Wang, Li, Guo: "Effects and mechanism of bufei yishen formula in a rat chronic obstructive pulmonary disease model." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 381976, (2014) (PubMed).

    Zhai, Han, Shan, Qu, Guo, Zhou: "Dual specificity phosphatase 6 suppresses the growth and metastasis of prostate cancer cells." dans: Molecular medicine reports, Vol. 10, Issue 6, pp. 3052-8, (2014) (PubMed).

    Zhang, Zhang, Deng, Li, Xing, Shi, Du: "Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus." dans: Neural regeneration research, Vol. 9, Issue 15, pp. 1446-52, (2014) (PubMed).

    Liu, Shan, Dong, Liu, Ma, Liu: "Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury." dans: World journal of gastroenterology, Vol. 19, Issue 4, pp. 492-502, (2013) (PubMed).

  • Antigène
    IL-8 (IL8) (Interleukin 8 (IL8))
    Autre désignation
    IL8 (IL8 Produits)
    Synonymes
    anticorps CXCL8, anticorps GCP-1, anticorps GCP1, anticorps LECT, anticorps LUCT, anticorps LYNAP, anticorps MDNCF, anticorps MONAP, anticorps NAF, anticorps NAP-1, anticorps NAP1, anticorps IL-8, anticorps AMCF-I, anticorps il8, anticorps IL8, anticorps si:dkey-151b16.2, anticorps cxcli2, anticorps cxcl8, anticorps gcp-1, anticorps il-8, anticorps lynap, anticorps mdncf, anticorps monap, anticorps nap-1, anticorps C-X-C motif chemokine ligand 8, anticorps interleukin 8, anticorps chemokine (C-X-C motif) ligand 8a, anticorps chemokine (C-X-C motif) ligand 1-like, anticorps chemokine (C-X-C motif) ligand 8 L homeolog, anticorps CXCL8, anticorps il8, anticorps cxcl8a, anticorps IL8, anticorps Cxcl8, anticorps LOC422654, anticorps cxcl8.L
    Sujet
    Interleukin-8(IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. Interleukin-8(IL8) is a member of the CXC chemokine family(Hull et al., 2001). IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. The genes for IL8 have been co-localized on a 335-kb genomic fragment.

    Synonyms: (Ala-IL-8)77 antibody|(Ser-IL-8)72 antibody|3 10C antibody|310C antibody|AMCF 1 antibody|AMCF1 antibody|b ENAP antibody|Bbeta thromboglobulin like protein antibody|Beta thromboglobulin like protein antibody|C-X-C motif chemokine 8 antibody|CXC chemokine ligand 8 antibody|CXCL 8 antibody|CXCL8 antibody|Emoctakin antibody|GCP 1 antibody|GCP-1 antibody|GCP/IL-8 protein I antibody|GCP/IL-8 protein II antibody|GCP/IL-8 protein III antibody|GCP/IL-8 protein IV antibody|GCP/IL-8 protein V antibody|GCP/IL-8 protein VI antibody|GCP1 antibody|Granulocyte chemotactic protein 1 antibody|IL 8 antibody|IL-8 antibody|IL-8(1-77) antibody|IL-8(9-77) antibody|IL8 antibody|IL8/NAP1 form I antibody|IL8/NAP1 form II antibody|IL8/NAP1 form III antibody|IL8/NAP1 form IV antibody|IL8/NAP1 form V antibody|IL8/NAP1 form VI antibody|IL8_HUMAN antibody|Inteleukin 8 antibody|Interleukin8 antibody|K 60 antibody|K60 antibody|LECT antibody|LUCT antibody|Lymphocyte derived neutrophil activating factor antibody|Lymphocyte-derived neutrophil-activating factor antibody|LYNAP antibody|MDNCF antibody|MDNCF-b antibody|MDNCF-c antibody|MONAP antibody|Monocyte derived neutrophil activating peptide antibody|Monocyte derived neutrophil activating protein antibody|Monocyte derived neutrophil chemotactic factor antibody|Monocyte-derived neutrophil chemotactic factor antibody|Monocyte-derived neutrophil-activating peptide antibody|NAF antibody|NAP 1 antibody|NAP-1 antibody|NAP1 antibody|Neutrophil activating factor antibody|Neutrophil activating peptide 1 antibody|Neutrophil activating protein 1 antibody|Neutrophil-activating factor antibody|Neutrophil-activating protein 1 antibody|Protein 3 10C antibody|Protein 3-10C antibody|SCYB 8 antibody|SCYB8 antibody|Small inducible cytokine subfamily B member 8 antibody|T cell chemotactic factor antibody|T-cell chemotactic factor antibody|TSG 1 antibody|TSG1 antibody
    UniProt
    P10145
    Pathways
    Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Hepatitis C, Autophagy
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