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Vitamin D Receptor anticorps (C-Term)

VDR Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3042969
  • Antigène Voir toutes Vitamin D Receptor (VDR) Anticorps
    Vitamin D Receptor (VDR)
    Épitope
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    AA 389-404, C-Term
    Reactivité
    • 91
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    • 2
    • 1
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    Humain
    Hôte
    • 98
    • 11
    • 1
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    Lapin
    Clonalité
    • 92
    • 19
    Polyclonal
    Conjugué
    • 56
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    Cet anticorp Vitamin D Receptor est non-conjugé
    Application
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    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for Vitamin D3 receptor(VDR) detection. Tested with WB in Human,Mouse,Rat.
    Séquence
    DLRSLNEEHS KQYRCL
    Réactivité croisée (Details)
    Predicted Cross Reactivity: mouse, rat
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Vitamin D3 receptor(VDR) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: vitamin D(1,25- dihydroxyvitamin D3) receptor
    Protein Name: Vitamin D3 receptor
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of human VDR (389-404aa DLRSLNEEHSKQYRCL), different from the related rat and mouse sequences by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product VDR Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, The detection limit for VDR is approximately 0.5 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Date de péremption
    12 months
  • Hou, Huang, Luo, Wang, Liu, Deng, Zhang, Liu, Chen: "MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR." dans: American journal of translational research, Vol. 9, Issue 11, pp. 4963-4973, (2017) (PubMed).

    Gao, Wang, Yan, Zeng, Ma, Niu, Zhou, Jiang, Chen: "Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats." dans: PLoS ONE, Vol. 11, Issue 3, pp. e0151118, (2016) (PubMed).

  • Antigène
    Vitamin D Receptor (VDR)
    Autre désignation
    VDR (VDR Produits)
    Synonymes
    anticorps vdrbeta, anticorps vdr0, anticorps LOC100136219, anticorps NR1I1-B, anticorps gb:dq017633, anticorps vdr-b, anticorps Ci-VDR-b, anticorps VDR, anticorps LOC100221284, anticorps vdr-A, anticorps xVDR, anticorps Nr1i1, anticorps vdr, anticorps NR1I1, anticorps PPP1R163, anticorps vitamin D (1,25- dihydroxyvitamin D3) receptor, anticorps vitamin D receptor, anticorps vitamin D3 receptor A, anticorps vitamin D receptor b, anticorps nuclear receptor VDR-b, anticorps vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog, anticorps vitamin D (1,25-dihydroxyvitamin D3) receptor, anticorps vitamin D receptor a, anticorps vdr, anticorps vdr0, anticorps VDR, anticorps LOC100136219, anticorps vdrb, anticorps vdr-b, anticorps vdr.L, anticorps Vdr, anticorps vdra
    Classe de substances
    Chemical
    Sujet
    VDR(Vitamin D Receptor), also known as Vitamin D Hormone Receptor, is a member of the nuclear receptor family of transcription factors. Labuda et al.(1991) assigned the VDR gene to 12q12-q14 by in situ hybridization. Using mutation analysis, Jurutka et al.(2000) characterized arg18/arg22, VDR residues immediately N-terminal of the first DNA-binding zinc finger, as vital for contact with the general transcription factor IIB(TFIIB). A natural polymorphic variant of VDR, termed F/M4(missing a FokI restriction site), which lacks only the first 3 amino acids(including glu2), interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length(f/M1) receptor. Shah et al.(2006) stated that the signaling and oncogenic activity of beta-catenin(CTNNB1) can be repressed by activation of VDR. Conversely, high levels of beta-catenin can potentiate the transcriptional activity of 1,25-dihydroxyvitamin D3.

    Synonyms: 1 25 dihydroxyvitamin D3 receptor antibody|1 antibody|1,25-@dihydroxyvitamin D3 receptor antibody|125 dihydroxyvitamin D3 receptor antibody|25-dihydroxyvitamin D3 receptor antibody|Member 1 antibody|NR1I1 antibody|Nuclear receptor subfamily 1 group I member 1 antibody|VDR antibody|VDR_HUMAN antibody|Vitamin D(1,25- dihydroxyvitamin D3) receptor antibody|Vitamin D hormone receptor antibody|Vitamin D nuclear receptor variant 1 antibody|Vitamin D receptor antibody|Vitamin D3 receptor antibody
    UniProt
    P11473
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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