MAP3K3 anticorps (N-Term)
-
- Antigène Voir toutes MAP3K3 Anticorps
- MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
-
Épitope
- AA 11-25, N-Term
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp MAP3K3 est non-conjugé
-
Application
- Western Blotting (WB)
- Fonction
- Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase kinase kinase 3(MAP3K3) detection. Tested with WB in Human.
- Séquence
- MNDLVALQMN RRHRM
- Réactivité croisée (Details)
- No cross reactivity with other proteins.
- Attributs du produit
-
Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase kinase kinase 3(MAP3K3) detection. Tested with WB in Human.
Gene Name: mitogen-activated protein kinase kinase kinase 3
Protein Name: Mitogen-activated protein kinase kinase kinase 3 - Purification
- Immunogen affinity purified.
- Immunogène
- A synthetic peptide corresponding to a sequence at the N-terminus of human MEKK3(11-25aa MNDLVALQMNRRHRM).
- Isotype
- IgG
- Top Product
- Discover our top product MAP3K3 Anticorps primaire
-
-
- Indications d'application
-
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MAP3K3 is approximately 0.5 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Commentaires
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Agent conservateur
- Thimerosal (Merthiolate), Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
-
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - Date de péremption
- 12 months
-
- Antigène
- MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
- Autre désignation
- MAP3K3 (MAP3K3 Produits)
- Synonymes
- anticorps MAPKKK3, anticorps MEKK3, anticorps AW548911, anticorps Mekk3, anticorps mKIAA4031, anticorps mitogen activated protein kinase kinase kinase 3, anticorps mitogen-activated protein kinase kinase kinase 3, anticorps Map3k3, anticorps MAP3K3, anticorps map3k3
- Sujet
-
MAP3K3(Mitogen-activated protein kinase kinase kinase 3), also known as MAP/ERK KINASE KINASE 3, MEKK3 or MAPKKK3, is an enzyme that in humans is encoded by the MAP3K3 gene. MAP3K3 is contiguously distal to LYK5 on chromosome 17(Puffenberger et al., 2007). By yeast 2-hybrid analysis of a mouse T-cell cDNA library, Uhlik et al.(2003) showed that a C-terminal fragment of mouse Osm(CCM2) interacted with Mekk3, which activates p38 in response to sorbitol-induced hyperosmotic conditions. Mekk3 and Osm colocalized in the cytoplasmic compartment of cotransfected cells, and the Mekk3-Osm complex was recruited to Rac1 and cytoskeletal actin-containing membrane ruffles in response to sorbitol treatment. Protein interaction assays showed that Osm interacted directly with the Mekk3 substrate Mkk3(MAP2K3), with actin, and with both GDP- and GTP-loaded Rac1. Uhlik et al.(2003) concluded that the RAC1-OSM-MEKK3-MKK3 complex is required for regulation of p38 activity in response to osmotic shock.
Synonyms: M3K3_HUMAN antibody|MAP/ERK kinase kinase 3 antibody|MAP3K3 antibody|MAPK/ERK kinase kinase 3 antibody|MAPKKK3 antibody|MEK kinase 3 antibody|MEKK 3 antibody|MEKK3 antibody|mitogen activated protein kinase kinase kinase 3 antibody|Mitogen-activated protein kinase kinase kinase 3 antibody - UniProt
- Q99759
- Pathways
- Signalisation MAPK
-