p53 anticorps (Tumor Protein P53)

Details for Product anti-TP53 Antibody No. ABIN3043664
Antigène
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Reactivité
Humain
2344
501
466
249
100
64
63
32
26
22
22
17
16
7
6
6
5
4
4
4
3
3
3
2
2
1
1
1
Hôte
Souris
1648
769
7
5
1
1
1
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp p53 est non-conjugé
89
62
48
41
40
40
40
39
39
38
33
32
14
12
12
12
12
11
8
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
6
5
2
2
2
Application
Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1835
766
747
574
436
412
370
155
109
102
98
89
75
41
32
16
15
15
13
3
2
2
1
1
1
1
1
1
1
1
1
1
Options
Fonction Mouse IgG monoclonal antibody for p53, tumor protein p53 (TP53) detection. Tested with WB, IHC-P, IHC-F, ICC in Human. No cross reactivity with other proteins.
Immunogène Recombinant human wild-type p53 protein.
Clone BP53-12
Isotype IgG2a
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Mouse IgG monoclonal antibody for p53, tumor protein p53 (TP53) detection. Tested with WB, IHC-P, IHC-F, ICC in Human.
Gene Name: tumor protein p53
Protein Name: Cellular tumor antigen p53
Purification Ascites
Plasmids, Primers & others Plasmids, Primers & others p53 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation TP53 (TP53 Antibody Extrait)
Sujet The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.

Synonyms: LFS1|TRP53|Li-Fraumeni syndrome|TRANSFORMATION-RELATED PROTEIN 53|Antigen NY-CO-13|Phosphoprotein p53|Tumor suppressor p53
ID gène 7157, 22059, 24842
UniProt P04637, P02340, P10361
Pathways Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy
Indications d'application WB: Concentration: 0.5-1 μg/mL, Species: Human
IHC-P: Concentration: 0.5-2 μg/mL, Species: Human
IHC-F: Concentration: 0.5-2 μg/mL, Species: Human
ICC: Concentration: 1 μg/mL, Species: Human
Notes: Other applications have not been tested. Optimal dilutions should be determined by end users.
Commentaires

Antibody can be supported by chemiluminescence kit ABIN921123 in WB, supported by ABIN921230 in IHC(P), IHC(F) and ICC.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 1 mL of PBS buffer will yield a concentration of 100 μg/mL.
Concentration 100 μg/mL
Buffer Mouse ascites fluid, 1.2 % sodium acetate, 2 mg BSA, with 0.01 mg Sodium azide as preservative.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) antibody (ABIN3043664) Anti-p53 antibody (monoclonal), IHC(P) IHC(P): Human Mammary Cancer Tissue
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) antibody (ABIN3043664) Anti-p53 antibody (monoclonal), Western blotting WB: HL-60 Cell Lysate
Produit citée dans: Liu, Kuang, Wu, Jin, Sun: "A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo." dans: Scientific reports, Vol. 6, pp. 26722, 2018 (PubMed).

Feng, Yan, Zhou, Liang, Liang, Zhao, Dong, Ling: "Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis." dans: Oncotarget, Vol. 7, Issue 40, pp. 64575-64588, 2018 (PubMed).

Liao, Xiao, Chen, Zhang, Chen, Long, Gao, He, Ge, Yi, Wu, Li, Zhou: "The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer." dans: International journal of oncology, Vol. 51, Issue 5, pp. 1497-1507, 2018 (PubMed).

Duan, Di: "Acetazolamide Suppresses Multi-Drug Resistance-Related Protein 1 and P-Glycoprotein Expression by Inhibiting Aquaporins Expression in a Mesial Temporal Epilepsy Rat Model." dans: Medical science monitor : international medical journal of experimental and clinical research, Vol. 23, pp. 5818-5825, 2018 (PubMed).

Liu, Wang, Kuang, Cao, Bao, Liu, Liu, Sun: "The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death." dans: Cell death & disease, Vol. 9, Issue 6, pp. 689, 2018 (PubMed).

Deng, Li, Lin, Huang, Zeng, Wang, Li, Jin, Zhang, Li, Chen, Wang, Huang, Shao, Xu, Mao: "P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride Channel-3." dans: Theranostics, Vol. 6, Issue 2, pp. 204-18, 2017 (PubMed).

Ren, Qiu, Lü, Ru, Li, Xiang, Yu, Zhang: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." dans: Scientific reports, Vol. 6, pp. 23775, 2017 (PubMed).

Wang, Xi, Jiang, Ji, Yu, Zhu, Zhang: "Metronomic chemotherapy remodel cancer-associated fibroblasts to decrease chemoresistance of gastric cancer in nude mice." dans: Oncology letters, Vol. 14, Issue 6, pp. 7903-7909, 2017 (PubMed).

Li, Tan, Chen, Xu, Yang, Ren, Guo, Wang, Chen, Li, Wang: "MDM4 overexpressed in acute myeloid leukemia patients with complex karyotype and wild-type TP53." dans: PLoS ONE, Vol. 9, Issue 11, pp. e113088, 2016 (PubMed).

Wei, Wang, Yu, Ye, Jiang, Cheng: "Expression of TP53, BCL-2, and VEGFA Genes in Esophagus Carcinoma and its Biological Significance." dans: Medical science monitor : international medical journal of experimental and clinical research, Vol. 21, pp. 3016-22, 2016 (PubMed).

Han, Liu, Li, Tian, Han, Wang, Fu, Guo, Zhu, Du, Tian: "HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0142387, 2016 (PubMed).

Zhang, Shang, Hao, Zheng, Li, Liang, Cui, Liu: "Effects of human umbilical cord mesenchymal stem cell transplantation combined with minimally invasive hematoma aspiration on intracerebral hemorrhage in rats." dans: American journal of translational research, Vol. 7, Issue 11, pp. 2176-86, 2016 (PubMed).

Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: "The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum." dans: Oncotarget, Vol. 7, Issue 24, pp. 35592-35606, 2016 (PubMed).

Xiao, Zhou, Yi, Luo, Jiang, Tian, Li, Xue: "Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro." dans: International journal of oncology, Vol. 46, Issue 4, pp. 1677-84, 2015 (PubMed).

Liang, Peng, Li, Yang, Xie, Li, Du, Zhang: "Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin." dans: Oncotarget, Vol. 6, Issue 2, pp. 1020-30, 2015 (PubMed).

Sasaki, Nitta, Sato, Nakanuma: "Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia." dans: Human pathology, Vol. 46, Issue 2, pp. 202-9, 2015 (PubMed).

Luo, Zhou, Yi, Yi: "Lactotransferrin expression is downregulated and affects the mitogen-activated protein kinase pathway in gastric cancer." dans: Oncology letters, Vol. 9, Issue 5, pp. 2409-2413, 2015 (PubMed).

Guo, Cui, Peng, Fang, Zuo, Deng, Wang, Wu, Chen, Deng: "Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney." dans: Oncotarget, Vol. 6, Issue 34, pp. 35964-77, 2015 (PubMed).

Jiang, Li, Zhou, Wang, Zhang, Wang: "Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways." dans: International journal of molecular medicine, Vol. 33, Issue 5, pp. 1298-304, 2014 (PubMed).

Dong, Wang: "Antitumor effects of artesunate on human breast carcinoma MCF-7 cells and IGF-IR expression in nude mice xenografts." dans: Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, Vol. 26, Issue 2, pp. 200-7, 2014 (PubMed).

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