ABCC4 anticorps (AA 1-370)

N° du produit ABIN3043774

Détail du produit anti-ABCC4 anticorps

Antigène: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Épitope: AA 1-370

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCC4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Protein Name: Multidrug resistance-associated protein 4

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MRP4 recombinant protein (Position: M1-P370).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MRP4 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur ABCC4

Antigène: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Autre désignation: ABCC4 (ABCC4 Produits)

Synonymes: anticorps EST170205, anticorps MOAT-B, anticorps MOATB, anticorps MRP4, anticorps D630049P08Rik, anticorps Mrp4, anticorps ATP binding cassette subfamily C member 4, anticorps multidrug resistance-associated protein 4, anticorps ATP-binding cassette, sub-family C (CFTR/MRP), member 4, anticorps ABCC4, anticorps LOC515333, anticorps LOC616707, anticorps LOC695407, anticorps abcc4, anticorps Abcc4

Sujet: ABCC4(Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Synonyms: ABCC 4 antibody|ABCC4 antibody|ATP binding cassette sub family C (CFTR/MRP) member 4 antibody|ATP binding cassette sub family C member 4 antibody|ATP-binding cassette sub-family C member 4 antibody|bA464I2.1 (ATP binding cassette, sub-family C (CFTR/MRP) member 4) antibody|bA464I2.1 antibody|Canalicular multispecific organic anion transporter ABC superfamily antibody|canalicular multispecific organic anion transporter antibodyEST170205 antibody|MOAT B antibody|MOAT-B antibody|MOATB antibody|MRP 4 antibody|MRP/cMOAT related ABC transporter antibody|MRP/cMOAT-related ABC transporter antibody|MRP4_HUMAN antibody|Multi specific organic anion transporter B antibody|Multi-specific organic anion transporter B antibody|Multidrug resistance associated protein 4 antibody|Multidrug resistance-associated protein 4 antibody|OTTHUMP00000018560 antibody

ID gène: 10257

UniProt: O15439