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FE65 anticorps (N-Term)

APBB1 Reactivité: Souris, Humain, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3043784
  • Antigène Voir toutes FE65 (APBB1) Anticorps
    FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
    Épitope
    • 15
    • 15
    • 15
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-56, N-Term
    Reactivité
    • 55
    • 37
    • 27
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Souris, Humain, Rat
    Hôte
    • 58
    • 1
    • 1
    Lapin
    Clonalité
    • 60
    Polyclonal
    Conjugué
    • 18
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp FE65 est non-conjugé
    Application
    • 59
    • 39
    • 39
    • 14
    • 9
    • 9
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for Amyloid beta A4 precursor protein-binding family B member 1(APBB1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Séquence
    ALSLPLPLHA AHNQLLNAKL QATAVGPKDL RSAMGE
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Amyloid beta A4 precursor protein-binding family B member 1(APBB1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
    Protein Name: Amyloid beta A4 precursor protein-binding family B member 1
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the N-terminus of human FE65 (21-56aa ALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGE), different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.
    Isotype
    IgG
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Antigène
    FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
    Autre désignation
    APBB1 (APBB1 Produits)
    Synonymes
    anticorps FE65, anticorps MGC:9072, anticorps RIR, anticorps apbb1, anticorps MGC80654, anticorps Fe65, anticorps Rir, anticorps amyloid beta precursor protein binding family B member 1, anticorps amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog, anticorps amyloid beta (A4) precursor protein-binding, family B, member 1, anticorps APBB1, anticorps apbb1.L, anticorps Apbb1
    Sujet
    APBB1 is also known as RIR or FE65. The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

    Synonyms: Adaptor protein FE65a2 antibody|Amyloid beta (A4) precursor protein binding family B member 1 antibody|Amyloid Beta A4 Precursor Protein Binding Family B antibody|Amyloid beta A4 precursor protein binding family B member 1 antibody|Amyloid beta A4 precursor protein-binding family B member 1 antibody|Amyloid beta precursor protein binding family B member 1 antibody|APBB 1 antibody|APBB1 antibody|APBB1_HUMAN antibody|FE 65 antibody|Fe65 protein antibody|Protein Fe65 antibody|RIR antibody|stat like protein antibody
    ID gène
    322
    UniProt
    O00213
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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