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MUC1 anticorps (AA 474-630)

MUC1 Reactivité: Souris, Rat WB, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3043886
  • Antigène Voir toutes MUC1 Anticorps
    MUC1 (Mucin 1 (MUC1))
    Épitope
    • 26
    • 19
    • 16
    • 16
    • 12
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 474-630
    Reactivité
    • 276
    • 57
    • 29
    • 12
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Souris, Rat
    Hôte
    • 197
    • 91
    • 2
    • 1
    Lapin
    Clonalité
    • 175
    • 111
    • 5
    Polyclonal
    Conjugué
    • 147
    • 26
    • 16
    • 12
    • 11
    • 11
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MUC1 est non-conjugé
    Application
    • 141
    • 138
    • 103
    • 86
    • 75
    • 47
    • 26
    • 25
    • 24
    • 20
    • 18
    • 14
    • 13
    • 13
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Fonction
    Rabbit IgG polyclonal antibody for Mucin-1(MUC1) detection. Tested with WB, IHC-P, IHC-F in Mouse,Rat.
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Mucin-1(MUC1) detection. Tested with WB, IHC-P, IHC-F in Mouse,Rat.
    Gene Name: mucin 1, cell surface associated
    Protein Name: Mucin-1
    Purification
    Immunogen affinity purified.
    Immunogène
    E.coli-derived mouse MUC1 recombinant protein (Position: S474-L630). Mouse MUC1 shares 87% amino acid (aa) sequence identity with human MUC1.
    Isotype
    IgG
    Top Product
    Discover our top product MUC1 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Mouse, The detection limit for MUC1 is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Liu, Wei, Yang, Tan, Sun, Li, Che, Luan, Wang, Wang, Sun, Yin: "Globose, cystic olfactory ensheathing cell tumor: A case report and literature review." dans: Oncology letters, Vol. 12, Issue 5, pp. 3981-3986, (2016) (PubMed).

    Zhang, Chen, Shi, Xie, Liu, Zhang, Lai, Zuo, Chen, Liu, Wang: "Establishment of a new representative model of human ovarian cancer in mice." dans: Journal of ovarian research, Vol. 6, Issue 1, pp. 9, (2013) (PubMed).

  • Antigène
    MUC1 (Mucin 1 (MUC1))
    Autre désignation
    MUC1 (MUC1 Produits)
    Synonymes
    anticorps CA 15-3, anticorps CD227, anticorps EMA, anticorps H23AG, anticorps KL-6, anticorps MAM6, anticorps MCKD1, anticorps MUC-1, anticorps MUC-1/SEC, anticorps MUC-1/X, anticorps MUC1/ZD, anticorps PEM, anticorps PEMT, anticorps PUM, anticorps Muc-1, anticorps mucin 1, cell surface associated, anticorps mucin 1, transmembrane, anticorps MUC1, anticorps Muc1
    Sujet
    Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.

    Synonyms: ADMCKD antibody|ADMCKD1 antibody|Breast carcinoma associated antigen DF3 antibody|Breast carcinoma-associated antigen DF3 antibody|CA 15-3 antibody|CA15 3 antibody|CA15 3 antigen antibody|CA15.3 antibody|Cancer antigen 15-3 antibody|Carcinoma associated mucin antibody|Carcinoma-associated mucin antibody|CD 227 antibody|CD227 antibody|DF3 antigen antibody|EMA antibody|Episialin antibody|H23 antigen antibody|H23AG antibody|KL 6 antibody|KL-6 antibody|KL6 antibody|Krebs von den Lungen-6 antibody|MAM 6 antibody|MAM6 antibody|MCD antibody|MCKD antibody|MCKD1 antibody|Medullary cystic kidney disease 1 (autosomal dominant) antibody|MUC 1 antibody|MUC-1 antibody|MUC-1/SEC antibody|MUC-1/X antibody|MUC1 antibody|MUC1-alpha antibody|MUC1-beta antibody|MUC1-CT antibody|MUC1-NT antibody|MUC1/ZD antibody|MUC1_HUMAN antibody|Mucin 1 antibody|Mucin 1 transmembrane antibody|Mucin 1, cell surface associated antibody|Mucin-1 subunit beta antibody|Peanut reactive urinary mucin antibody|Peanut-reactive urinary mucin antibody|PEM antibody|PEMT antibody|Polymorphic epithelial mucin antibody|PUM antibody|Tumor associated epithelial membrane antigen antibody|Tumor associated epithelial mucin antibody|Tumor associated mucin antibody|Tumor-associated epithelial membrane antigen antibody|Tumor-associated mucin antibody
    ID gène
    17829
    UniProt
    Q02496
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
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