MUC1 anticorps (AA 474-630)
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- Antigène Voir toutes MUC1 Anticorps
- MUC1 (Mucin 1 (MUC1))
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Épitope
- AA 474-630
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Reactivité
- Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MUC1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Fonction
- Rabbit IgG polyclonal antibody for Mucin-1(MUC1) detection. Tested with WB, IHC-P, IHC-F in Mouse,Rat.
- Réactivité croisée (Details)
- No cross reactivity with other proteins.
- Attributs du produit
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Rabbit IgG polyclonal antibody for Mucin-1(MUC1) detection. Tested with WB, IHC-P, IHC-F in Mouse,Rat.
Gene Name: mucin 1, cell surface associated
Protein Name: Mucin-1 - Purification
- Immunogen affinity purified.
- Immunogène
- E.coli-derived mouse MUC1 recombinant protein (Position: S474-L630). Mouse MUC1 shares 87% amino acid (aa) sequence identity with human MUC1.
- Isotype
- IgG
- Top Product
- Discover our top product MUC1 Anticorps primaire
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- Indications d'application
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Mouse, The detection limit for MUC1 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - Commentaires
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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Globose, cystic olfactory ensheathing cell tumor: A case report and literature review." dans: Oncology letters, Vol. 12, Issue 5, pp. 3981-3986, (2016) (PubMed).
: "Establishment of a new representative model of human ovarian cancer in mice." dans: Journal of ovarian research, Vol. 6, Issue 1, pp. 9, (2013) (PubMed).
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Globose, cystic olfactory ensheathing cell tumor: A case report and literature review." dans: Oncology letters, Vol. 12, Issue 5, pp. 3981-3986, (2016) (PubMed).
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- Antigène
- MUC1 (Mucin 1 (MUC1))
- Autre désignation
- MUC1 (MUC1 Produits)
- Synonymes
- anticorps CA 15-3, anticorps CD227, anticorps EMA, anticorps H23AG, anticorps KL-6, anticorps MAM6, anticorps MCKD1, anticorps MUC-1, anticorps MUC-1/SEC, anticorps MUC-1/X, anticorps MUC1/ZD, anticorps PEM, anticorps PEMT, anticorps PUM, anticorps Muc-1, anticorps mucin 1, cell surface associated, anticorps mucin 1, transmembrane, anticorps MUC1, anticorps Muc1
- Sujet
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Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.
Synonyms: ADMCKD antibody|ADMCKD1 antibody|Breast carcinoma associated antigen DF3 antibody|Breast carcinoma-associated antigen DF3 antibody|CA 15-3 antibody|CA15 3 antibody|CA15 3 antigen antibody|CA15.3 antibody|Cancer antigen 15-3 antibody|Carcinoma associated mucin antibody|Carcinoma-associated mucin antibody|CD 227 antibody|CD227 antibody|DF3 antigen antibody|EMA antibody|Episialin antibody|H23 antigen antibody|H23AG antibody|KL 6 antibody|KL-6 antibody|KL6 antibody|Krebs von den Lungen-6 antibody|MAM 6 antibody|MAM6 antibody|MCD antibody|MCKD antibody|MCKD1 antibody|Medullary cystic kidney disease 1 (autosomal dominant) antibody|MUC 1 antibody|MUC-1 antibody|MUC-1/SEC antibody|MUC-1/X antibody|MUC1 antibody|MUC1-alpha antibody|MUC1-beta antibody|MUC1-CT antibody|MUC1-NT antibody|MUC1/ZD antibody|MUC1_HUMAN antibody|Mucin 1 antibody|Mucin 1 transmembrane antibody|Mucin 1, cell surface associated antibody|Mucin-1 subunit beta antibody|Peanut reactive urinary mucin antibody|Peanut-reactive urinary mucin antibody|PEM antibody|PEMT antibody|Polymorphic epithelial mucin antibody|PUM antibody|Tumor associated epithelial membrane antigen antibody|Tumor associated epithelial mucin antibody|Tumor associated mucin antibody|Tumor-associated epithelial membrane antigen antibody|Tumor-associated mucin antibody - ID gène
- 17829
- UniProt
- Q02496
- Pathways
- Negative Regulation of intrinsic apoptotic Signaling
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