ABCC1 anticorps (C-Term)

N° du produit ABIN3044230

Détail du produit anti-ABCC1 anticorps

Antigène: ABCC1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1))

Épitope: AA 1514-1531, C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 1(ABCC1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: LLQQRGLFYS MAKDAGLV

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 1(ABCC1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: ATP-binding cassette, sub-family C(CFTR/MRP), member 1
Protein Name: Multidrug resistance-associated protein 1

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1(1514-1531aa, LLQQRGLFYSMAKDAGLV), different from the related rat and mouse sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Références pour anticorps anti-ABCC1 (ABIN3044230)

Duan, Di: "Acetazolamide Suppresses Multi-Drug Resistance-Related Protein 1 and P-Glycoprotein Expression by Inhibiting Aquaporins Expression in a Mesial Temporal Epilepsy Rat Model." dans: Medical science monitor : international medical journal of experimental and clinical research, Vol. 23, pp. 5818-5825, (2018) (PubMed).

Chen, Wei, Cheng, Xie, Wang, Yi, Tian, Liu, Wang, Zhang: "Characteristics of doxorubicin-selected multidrug-resistant human leukemia HL-60 cells with tolerance to arsenic trioxide and contribution of leukemia stem cells." dans: Oncology letters, Vol. 15, Issue 1, pp. 1255-1262, (2018) (PubMed).

Gao, Xu, Qiu: "Enhanced combination therapy effect on paclitaxel-resistant carcinoma by chloroquine co-delivery via liposomes." dans: International journal of nanomedicine, Vol. 10, pp. 6615-32, (2016) (PubMed).

Zhang, Yang, Wang, Liu, Wang, Xie, Chen, Dong, Li: "Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells." dans: Apoptosis : an international journal on programmed cell death, Vol. 21, Issue 4, pp. 473-88, (2016) (PubMed).

Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: "Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line." dans: Asian Pacific journal of cancer prevention : APJCP, Vol. 14, Issue 9, pp. 4983-8, (2013) (PubMed).

Wang, Fang, Huang, Chen, Fan, Wang: "The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats." dans: Environmental toxicology and pharmacology, Vol. 35, Issue 1, pp. 109-16, (2013) (PubMed).

Détails sur ABCC1

Antigène: ABCC1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1))

Autre désignation: ABCC1 (ABCC1 Produits)

Synonymes: anticorps ABC29, anticorps ABCC, anticorps GS-X, anticorps MRP, anticorps MRP1, anticorps Abcc1a, anticorps Abcc1b, anticorps Mdrap, anticorps Mrp1, anticorps Avcc1a, anticorps Mrp, anticorps ABCC13, anticorps ATP binding cassette subfamily C member 1, anticorps ATP-binding cassette, sub-family C (CFTR/MRP), member 1, anticorps multidrug resistance-associated protein 1, anticorps ABCC1, anticorps Abcc1, anticorps LOC100152428, anticorps LOC100346553

Sujet: Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.

Synonyms: ABC 29 antibody|ABC29 antibody|ABCC 1 antibody|ABCC antibody|ABCC1 antibody|ATP binding cassette sub family C(CFTR/MRP) member 1 antibody|ATP binding cassette sub-family C member 1 antibody|ATP-binding cassette sub-family C member 1 antibody|DKFZp686N04233 antibody|DKFZp781G125 antibody|GS X antibody|GSX antibody|Leukotriene C(4) transporter antibody|LTC4 transporter antibody|MRP 1 antibody|MRP antibody|MRP1_HUMAN antibody|Multidrug resistance associated protein 1 antibody|Multidrug resistance protein antibody|Multidrug resistance-associated protein 1 antibody|Multiple drug resistance associated protein antibody|Multiple drug resistance protein 1 antibody

UniProt: P33527

Pathways: SARS-CoV-2 Protein Interactome