Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

CYP11A1 anticorps (C-Term)

CYP11A1 Reactivité: Humain WB, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3044268
  • Antigène Voir toutes CYP11A1 Anticorps
    CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))
    Épitope
    • 16
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 507-521, C-Term
    Reactivité
    • 48
    • 25
    • 24
    • 17
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 50
    • 3
    Lapin
    Clonalité
    • 52
    • 1
    Polyclonal
    Conjugué
    • 34
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CYP11A1 est non-conjugé
    Application
    • 50
    • 15
    • 14
    • 13
    • 13
    • 10
    • 8
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Fonction
    Rabbit IgG polyclonal antibody for Cholesterol side-chain cleavage enzyme, mitochondrial(CYP11A1) detection. Tested with WB, IHC-P, IHC-F in Human.
    Séquence
    ISFTFWPFNQ EATQQ
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Cholesterol side-chain cleavage enzyme, mitochondrial(CYP11A1) detection. Tested with WB, IHC-P, IHC-F in Human.
    Gene Name: cytochrome P450, family 11, subfamily A, polypeptide 1
    Protein Name: Cholesterol side-chain cleavage enzyme, mitochondrial
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of human CYP11A1(507-521aa ISFTFWPFNQEATQQ).
    Isotype
    IgG
    Top Product
    Discover our top product CYP11A1 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Date de péremption
    12 months
  • He, Xu, Chen, Liu, Xi: "Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients." dans: PLoS ONE, Vol. 8, Issue 3, pp. e59609, (2013) (PubMed).

  • Antigène
    CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))
    Autre désignation
    CYP11A1 (CYP11A1 Produits)
    Synonymes
    anticorps CYP11A, anticorps CYP11A1, anticorps CYPXIA1, anticorps P450SCC, anticorps Cyp11a, anticorps Cypxia1, anticorps D9Ertd411e, anticorps P450scc, anticorps Scc, anticorps cscc, anticorps P450(scc), anticorps SSC, anticorps cytochrome P450 family 11 subfamily A member 1, anticorps cholesterol side-chain cleavage enzyme, mitochondrial-like, anticorps cytochrome P450 cholesterol side-chain cleavage, anticorps cytochrome P450, family 11, subfamily a, polypeptide 1, anticorps cytochrome P450, family 11, subfamily A, polypeptide 1, anticorps CYP11A1, anticorps LOC101827747, anticorps Cyp11a1
    Sujet
    CYP11A1(Cytochrome p450, family 11, subfamily A, polypeptide 1), also called CYTOCHROME P450SCC, CYTOCHROME P450C11A1 or CYP11A, is a mitochondrial enzyme associated with the conversion of cholesterol to pregnenolone. CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The CYP11A1 gene is mapped on 15q24.1. Expression of the CYP11A1 gene may play a role in skin physiology and pathology and that cutaneous proopiomelanocortin activity may be autoregulated by a feedback mechanism involving glucocorticoids synthesized locally by Slominski et al. Using in vitro studies, CYP11A1 catalyzed the side-chain cleavage of 7-dehydrocholesterol to form 7-dehydropregnenolone. In addition, CYP11A1 catalyzed the metabolism of biologically inert vitamin D3, which is formed from 7-dehydrocholesterol, to form 2 hydroxylated products, 20-hydroxyvitamin D3 and 20, 22-dihydroxyvitamin D3. Mutations in the CYP11A1 gene cause congenital adrenal insufficiency with partial or complete 46, XY sex reversal.

    Synonyms: Cholesterol 20 22 desmolase antibody|Cholesterol desmolase antibody|Cholesterol monooxygenase(side chain cleaving) antibody|Cholesterol side chain cleavage enzyme antibody|Cholesterol side chain cleavage enzyme mitochondrial antibody|Cholesterol side-chain cleavage enzyme antibody|CP11A_HUMAN antibody|CYP 11A antibody|CYP11A antibody|CYP11A1 antibody|CYPXIA1 antibody|Cytochrome P450 11A1 antibody|Cytochrome P450 11A1 mitochondrial antibody|Cytochrome P450 family 11 subfamily A polypeptide 1 antibody|Cytochrome P450 subfamily XIA(cholesterol side chain cleavage) antibody|Cytochrome P450 subfamily XIA antibody|Cytochrome P450(scc) antibody|Cytochrome P450C11A1 antibody|mitochondrial antibody|P450(scc) antibody|P450SCC antibody|Steroid 20 22 lyase antibody
    UniProt
    P05108
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin
Vous êtes ici:
Support technique