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GRIN1/NMDAR1 anticorps (N-Term)

GRIN1 Reactivité: Humain, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3044347
  • Antigène Voir toutes GRIN1/NMDAR1 (GRIN1) Anticorps
    GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))
    Épitope
    • 34
    • 27
    • 22
    • 17
    • 15
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 36-53, N-Term
    Reactivité
    • 133
    • 127
    • 102
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    • 136
    • 32
    • 1
    • 1
    Lapin
    Clonalité
    • 129
    • 41
    Polyclonal
    Conjugué
    • 73
    • 10
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp GRIN1/NMDAR1 est non-conjugé
    Application
    • 121
    • 58
    • 42
    • 41
    • 40
    • 28
    • 20
    • 18
    • 13
    • 10
    • 10
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for Glutamate receptor ionotropic, NMDA 1(GRIN1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Séquence
    RKHEQMFREA VNQANKRH
    Réactivité croisée (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Glutamate receptor ionotropic, NMDA 1(GRIN1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1
    Protein Name: Glutamate receptor ionotropic, NMDA 1
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the N-terminus of human NMDAR1(36-53aa RKHEQMFREAVNQANKRH), identical to the related rat and mouse sequences.
    Isotype
    IgG
    Top Product
    Discover our top product GRIN1 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Feng, Du: "Mechanisms responsible for the effect of median nerve electrical stimulation on traumatic brain injury-induced coma: orexin-A-mediated N-methyl-D-aspartate receptor subunit NR1 upregulation." dans: Neural regeneration research, Vol. 11, Issue 6, pp. 951-6, (2016) (PubMed).

    Wang, Wang, Fu, Zhang, Wu, Guo, Wang: "Expression of N-methyl-d-aspartate receptor 1 and its phosphorylated state in basal ganglia of a neonatal piglet hypoxic-ischemic brain injury model: a controlled study of (1)H MRS." dans: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, Vol. 16, Issue 5, pp. 492-500, (2012) (PubMed).

    Shang, Luo, Deng, Wang, Huang, Feng, Yue: "Expression of N-methyl-D-aspartate receptor and its effect on nitric oxide production of rat alveolar macrophages." dans: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, Vol. 23, Issue 4, pp. 327-31, (2010) (PubMed).

  • Antigène
    GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))
    Autre désignation
    GRIN1 (GRIN1 Produits)
    Synonymes
    anticorps GluN1, anticorps MRD8, anticorps NMDA1, anticorps NMDAR1, anticorps NR1, anticorps nmda1, anticorps nmdar1, anticorps GB19253, anticorps GRIN1, anticorps NMD-R1, anticorps Z16, anticorps GluRdelta1, anticorps GluRzeta1, anticorps M100174, anticorps Nmdar, anticorps Rgsc174, anticorps NMDAR1.1, anticorps zgc:152678, anticorps glutamate ionotropic receptor NMDA type subunit 1, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 1 S homeolog, anticorps NMDA receptor 1, anticorps G protein-regulated inducer of neurite outgrowth 1, anticorps glutamate receptor, ionotropic, NMDA1 (zeta 1), anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 1a, anticorps GRIN1, anticorps grin1.S, anticorps grin1, anticorps Grin1, anticorps Nmdar1, anticorps Gprin1, anticorps grin1a
    Sujet
    The NMDA receptor(NMDAR) is a specific type of ionotropic glutamate receptor. NMDA(N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties. It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'. The gene is a candidate for the site of the mutation in torsion dystonia.The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.

    Synonyms: GluN1 antibody|Glutamate[NMDA] receptor subunit zeta 1 antibody|Glutamate[NMDA] receptor subunit zeta-1 antibody|Glutamate receptor ionotropic N methyl D aspartate 1 antibody|Grin 1 antibody|Grin1 antibody|MRD8 antibody|N methyl D aspartate receptor antibody|N methyl D aspartate receptor channel antibody|N methyl D aspartate receptor channel subunit zeta 1 antibody|N methyl D aspartate receptor subunit NR1 antibody|N-methyl-D-aspartate receptor antibody|N-methyl-D-aspartate receptor subunit NR1 antibody|NMD-R1 antibody|NMDA 1 antibody|NMDA NR1 antibody|NMDA R1 antibody|NMDA receptor 1 antibody|NMDA1 antibody|NMDAR 1 antibody|NMDAR antibody|Nmdar1 antibody|NMDZ1_HUMAN antibody|NR 1 antibody|NR1 antibody
    UniProt
    Q05586
    Pathways
    Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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