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CCR10 anticorps (C-Term)

CCR10 Reactivité: Humain, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3044415
  • Antigène Voir toutes CCR10 Anticorps
    CCR10 (Chemokine (C-C Motif) Receptor 10 (CCR10))
    Épitope
    • 14
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 312-327, C-Term
    Reactivité
    • 48
    • 18
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Rat
    Hôte
    • 40
    • 4
    • 3
    • 2
    • 1
    Lapin
    Clonalité
    • 44
    • 6
    Polyclonal
    Conjugué
    • 27
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CCR10 est non-conjugé
    Application
    • 31
    • 29
    • 12
    • 10
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for C-C chemokine receptor type 10(CCR10) detection. Tested with WB in Human,Mouse,Rat.
    Séquence
    FLGLRFRQDL RRLLRG
    Réactivité croisée (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Attributs du produit
    Rabbit IgG polyclonal antibody for C-C chemokine receptor type 10(CCR10) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: chemokine(C-C motif) receptor 10
    Protein Name: C-C chemokine receptor type 10(C-C CKR-10/CC-CKR-10/CCR-10)
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of human GPR2/CCR10(312-327aa FLGLRFRQDLRRLLRG), different from the related rat and mouse sequences by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product CCR10 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Date de péremption
    12 months
  • Antigène
    CCR10 (Chemokine (C-C Motif) Receptor 10 (CCR10))
    Autre désignation
    CCR10 (CCR10 Produits)
    Synonymes
    anticorps GPR2, anticorps Cmkbr9, anticorps Gpr2, anticorps zgc:91924, anticorps CCR10, anticorps C-C motif chemokine receptor 10, anticorps chemokine (C-C motif) receptor 10, anticorps CCR10, anticorps Ccr10, anticorps ccr10
    Sujet
    CCR10, C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. CCR10 is constitutively expressed in skin melanocytes, fibroblasts, and microvascular endothelial cells, and that it is upregulated by IL1B and TNF. Expression was also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in dendritic cells.By fluorescence in situ hybridization, the GPR2 gene is mapped to 17q21.1-q21.3. CCR10 is the receptor for CCL27. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation. expression of CCL27 in normal keratinocytes and its strong upregulation in skin lesions of atopic dermatitis, contact dermatitis, and psoriasis patients. CCR10+ T lymphocytes were detected in lesional but not normal skin of these patients. Flow cytometric analysis showed that CCL27 binds extracellular matrix components and dermal microvascular endothelial cells and fibroblasts and mediates adhesion and transendothelial migration of CCR10+ circulating leukocytes. CCR10 is predominantly expressed on CD4+CLA+(cutaneous lymphocyte antigen), rather than CD8+, circulating T cells. RT-PCR, confocal microscopy, and ELISA analysis indicated that keratinocytes exposed to TNF or IL1B but not to IL4 or IFNG in vitro express increased CCL27.

    Synonyms: C C chemokine receptor type 10 antibody|C C CKR 10 antibody|C-C chemokine receptor type 10 antibody|C-C CKR-10 antibody|CC chemokine receptor 10 antibody|CC CKR 10 antibody|CC-CKR-10 antibody|CCR 10 antibody|CCR-10 antibody|CCR10 antibody|CCR10_HUMAN antibody|Chemokine(C C motif) receptor 10 antibody|G protein coupled receptor 2 antibody|G protein-coupled receptor 2 antibody|G-protein coupled receptor 2 antibody|GPR 2 antibody|GPR2 antibody
    UniProt
    P46092
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