RIT2 anticorps

N° du produit ABIN306806

Détail du produit anti-RIT2 anticorps

Antigène: RIT2 (Ras-Like Without CAAX 2 (RIT2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RIT2 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Souris

Attributs du produit: Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.

Immunogène: Hybridoma produced by the fusion of splenocytes from mice immunized with full-length recombinant human Rin protein and mouse myeloma cells.

Clone: 27G2

Isotype: IgG2b

Information d'application

Indications d'application: Antibody detects recombinant Rin protein expressed in 293 cells by Western blot analysis at a concentration of 0.5 to 1 μg/mL. Does not cross-react with Rit protein. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as sterile filtered solution containing 20 mM sodium phosphate, 150 mM sodium chloride, 50 % glycerol at pH 7.5 and 3 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur RIT2

Antigène: RIT2 (Ras-Like Without CAAX 2 (RIT2))

Autre désignation: Rin (RIT2 Produits)

Synonymes: anticorps RIBA, anticorps RIN, anticorps ROC2, anticorps Rin, anticorps Rit1, anticorps Roc2, anticorps RIT2, anticorps Ras like without CAAX 2, anticorps Ras-like without CAAX 2, anticorps RIT2, anticorps Rit2

UniProt: Q13671

Pathways: Neurotrophin Signaling Pathway