Macrophage Mannose Receptor 1 anticorps

N° du produit ABIN316963

Détail du produit anti-Macrophage Mannose Receptor 1 anticorps

Antigène: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Macrophage Mannose Receptor 1 est non-conjugé

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody is specific for CD206, otherwise known as Macrophage Mannose Receptor (MMR).

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: Macrophage mannose receptor 1, MMR, Dendritic Cell Marker, CLEC13D, Mannose ReceptorC type 1, C-type lectin domain family 13

Purification: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogène: Monocyte-derived dendritic cells. Remarks: Spleen cells from immunised Balb/c mice were fused with cells of theX63-Ag8. 653 myeloma cell line.

Clone: 30-06-50

Isotype: IgG2a

Information d'application

Indications d'application: Immunohistochemistry on Frozen Sections: 1/50-1/500. Positive Control: Human Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-Macrophage Mannose Receptor 1 (ABIN316963)

Grønbæk, Rødgaard-Hansen, Aagaard, Arroyo, Moestrup, Garcia, Solà, Domenicali, Piano, Vilstrup, Møller: "Macrophage activation markers predict mortality in patients with liver cirrhosis without or with acute-on-chronic liver failure (ACLF)." dans: Journal of hepatology, Vol. 64, Issue 4, pp. 813-22, (2016) (PubMed).

Vilahur, Cubedo, Padró, Casaní, Juan-Babot, Crespo, Bendjama, Lawton, Badimon: "Roflumilast-induced Local Vascular Injury Is Associated with a Coordinated Proteome and Microparticle Change in the Systemic Circulation in Pigs." dans: Toxicologic pathology, Vol. 43, Issue 4, pp. 569-80, (2016) (PubMed).

Rødgaard-Hansen, Rafique, Christensen, Maniecki, Sandahl, Nexø, Møller: "A soluble form of the macrophage-related mannose receptor (MR/CD206) is present in human serum and elevated in critical illness." dans: Clinical chemistry and laboratory medicine, Vol. 52, Issue 3, pp. 453-61, (2014) (PubMed).

Andersen, Krzystanek, Petersen, Bomholtz, Olesen, Abriel, Jespersen, Rasmussen: "A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 36841-54, (2014) (PubMed).

Silk, Leishman, Nishimoto, Reddy, Fairchild: "Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype." dans: Journal of biomedicine & biotechnology, Vol. 2012, pp. 172420, (2012) (PubMed).

Winkler, Doster, Jones: "Bovine herpesvirus 1 can infect CD4(+) T lymphocytes and induce programmed cell death during acute infection of cattle." dans: Journal of virology, Vol. 73, Issue 10, pp. 8657-68, (1999) (PubMed).

Détails sur Macrophage Mannose Receptor 1

Antigène: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Autre désignation: CD206 / MRC1 (MRC1 Produits)

Synonymes: anticorps CD206, anticorps CLEC13D, anticorps CLEC13DL, anticorps MMR, anticorps MRC1L1, anticorps bA541I19.1, anticorps AW259686, anticorps MR, anticorps mrc1, anticorps MGC86525, anticorps MRC1, anticorps MRC1L-A, anticorps mannose receptor C-type 1, anticorps mannose receptor, C type 1, anticorps mannose receptor C-type 1 L homeolog, anticorps mediator of replication checkpoint 1, anticorps MRC1, anticorps Mrc1, anticorps mrc1.L, anticorps mrc1

Sujet: CD206 is a transmembrane protein and member of the multilectin family of pattern recognition receptors (PRRs), which mediates phagocytosis and endocytosis, and is modulated by a range of factors including cytokines, immunoglobulin receptors and pathogens. CD206 has two extracellular lectin binding sites: the cysteine-rich domain binds to sulphated sugars of glycoproteins such as thyroid stimulating hormone, whilst the recognition of mannose and fucose occurs through carbohydrate recognition domains (CRDs). The widespread distribution and recognition of a wide range of antigens by macrophages, plays a key role in both innate and adaptive immunity, with CD206 able to bind to both gram-negative and gram-positive bacteria, mycobacterium, yeasts, fungi and parasites. The expression of CD206 is not restricted to macrophages, but is also present on immature dendritic cells (DCs), endothelial cells, kidney mesangial cells, retinal pigment epithelium and tracheal smooth muscle cells.Synonyms: C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, CLEC13D, CLEC13DL, MRC1L1, Macrophage mannose receptor, Macrophage mannose receptor 1-like protein 1

UniProt: P22897