SCNN1D anticorps

N° du produit ABIN317816

Détail du produit anti-SCNN1D anticorps

Antigène: SCNN1D (Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCNN1D est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects endogenous levels of ENaCδ protein. (region surrounding Pro446)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SCNN1D

Antigène: SCNN1D (Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D))

Autre désignation: ENAC delta / SCNN1D (SCNN1D Produits)

Synonymes: anticorps Scnn1d, anticorps SCNN1D, anticorps ENaCd, anticorps ENaCdelta, anticorps SCNED, anticorps dNaCh, anticorps sodium channel, nonvoltage-gated 1, delta, anticorps sodium channel epithelial 1 delta subunit, anticorps Gm20552, anticorps SCNN1D

Sujet: The epithelial sodium channel (ENaC) is a member of the ENaC/DEG superfamily that is located on the apical surface of cells. ENaC mediates sodium reabsorption in kidney, distal colon, lung, ducts of exocrine glands and other organs. ENaC is formed by heteromultimerization of four homologous subunits, α, β, γ and δ. The most frequently formed heterotetramer consists of 2α, 1β, and 1γ subunit, but the α subunit can be replaced by a δ subunit. The αENaC gene maps to human chromosome 12p13, and expresses a glycosylated protein. Both the β and γENaC genes map to human chromosome 16p12, and the γENaC transcript is detected as a glycosylated protein. The carboxy-terminus of all ENaC subunits contains PY motifs, which interact with the ubiquitin protein ligase, Nedd4, to regulate intracellular sodium concentrations. Gain-of-function mutations involving the PY motif cause Liddle's syndrome, an autosomal dominant form of hypertension, resulting from excessive renal sodium absorption. Conversely, ENaC loss-of-function mutations result in pseudohypoaldosteronism type I, a disorder characterized by salt wasting and hypotension.Synonyms: Amiloride-sensitive sodium channel subunit delta, DNACH, Delta-ENaC, Delta-NaCH, ENaCD, Epithelial Na(+) channel subunit delta, Nonvoltage-gated sodium channel 1 subunit delta, SCNED

Poids moléculaire: approx. 80 kDa

ID gène: 6339

NCBI Accession: NP_001123885

UniProt: P51172