SERPINA5
Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Cobaye, Porc, Drosophila melanogaster, Hamster
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps 4933415L04, anticorps PAI-3, anticorps Pci, anticorps PAI3, anticorps PCI, anticorps PCI-B, anticorps PLANH3, anticorps PROCI, anticorps serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5, anticorps serpin family A member 5, anticorps serine (or cysteine) peptidase inhibitor, clade A, member 5, anticorps plasma serine protease inhibitor, anticorps SPIA5, anticorps SERPINA5, anticorps Serpina5, anticorps LOC480424
Sujet
PAI-1, PAI-2 and PAI-3 (plasminogen activator inhibitor-1, -2 and -3) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 regulate uPA (urokinase-type plasminogen activator) and TPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. PAI-3 inhibits plasminogen activators as well as activated protein C. PAI-3 is secreted in plasma, but is also expressed in liver.Synonyms: Acrosomal serine protease inhibitor, PAI-3, PAI3, PCI, PLANH3, PROCI, Plasma serine protease inhibitor, Plasminogen activator inhibitor 3, Protein C inhibitor, Serpin A5