FAIM3 anticorps (C-Term)

N° du produit ABIN318759

Détail du produit anti-FAIM3 anticorps

Antigène: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAIM3 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects an epitope within the C-terminal (CT) region of Human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). In Western Bloting, This antibody detects a band of approximately 43 kDa in Human lung tissue lysate.

Réactivité croisée (Details): Species reactivity (expected):Rat and Mouse.
Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogène: A 13 amino acid peptide from near the carboxy terminus of Human Toso. Genename: TOSO

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1 - 2g/mL, detects a band of approximately 43 kDa in human lung tissuelysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur FAIM3

Antigène: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Autre désignation: FAIM3 / TOSO (FAIM3 Produits)

Synonymes: anticorps FAIM3, anticorps FCMR, anticorps TOSO, anticorps 1810037B05Rik, anticorps FcmuR, anticorps Toso, anticorps Fc fragment of IgM receptor, anticorps FCMR, anticorps Fcmr

Sujet: Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS PAGE.Synonyms: Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso

ID gène: 9214

NCBI Accession: NP_001135945

UniProt: O60667