THRB anticorps (Isoform 1, N-Term)

N° du produit ABIN349600

Détail du produit anti-THRB anticorps

Antigène: THRB (Thyroid Hormone Receptor, beta (THRB))

Épitope: Isoform 1, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THRB est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Souris, Rat (Rattus)

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the of human THRB protein.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blotting.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-THRB (ABIN349600)

Fozzatti, Park, Zhao, Willingham, Cheng: "Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer." dans: PLoS ONE, Vol. 8, Issue 6, pp. e67954, (2017) (PubMed).

Zhao, Zhu, Won Park, Fozzatti, Willingham, Cheng: "Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor." dans: Endocrinology, Vol. 153, Issue 10, pp. 5090-100, (2012) (PubMed).

Mascanfroni, Montesinos, Alamino, Susperreguy, Nicola, Ilarregui, Masini-Repiso, Rabinovich, Pellizas: "Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling." dans: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9569-82, (2010) (PubMed).

Détails sur THRB

Antigène: THRB (Thyroid Hormone Receptor, beta (THRB))

Autre désignation: Thyroid Hormone Receptor beta 1 (THRB Produits)

Synonymes: anticorps C-ERBA-2, anticorps C-ERBA-BETA, anticorps ERBA2, anticorps GRTH, anticorps NR1A2, anticorps PRTH, anticorps THR1, anticorps THRB1, anticorps THRB2, anticorps Nr1a2, anticorps T3R[b], anticorps T3Rbeta, anticorps Thrb1, anticorps Thrb2, anticorps c-erbAbeta, anticorps TR-beta, anticorps TR[b]1, anticorps fj24f03, anticorps trb, anticorps wu:fj24f03, anticorps CTR BETA 2, anticorps TR-BETA, anticorps LOC734147, anticorps thrb, anticorps THRB, anticorps C-erba-beta, anticorps RATT3REC, anticorps T3rec, anticorps TRbeta, anticorps THR, anticorps TRbeta1, anticorps thyroid hormone receptor beta, anticorps thyroid hormone receptor, beta, anticorps thyroid hormone receptor, beta S homeolog, anticorps thyroid hormone receptor, beta L homeolog, anticorps THRB, anticorps Thrb, anticorps thrb, anticorps thrb.S, anticorps thrb.L

Sujet: Anti-Thyroid Hormone Receptor ß1 (TRB1) antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). This TRB1 antibody is ideal for Immunology, Thyroid and Signal Tranduction research.
Synonyms: Thyroid hormone receptor beta TRB1 TR beta signaling c-erbA-beta c-erbA-2 Nuclear receptor subfamily 1 group A member 2

ID gène: 7068, 40806162

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound