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NGFR anticorps (Extracellular Domain)

NGFR Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN350712
  • Antigène Voir toutes NGFR Anticorps
    NGFR (Nerve Growth Factor Receptor (NGFR))
    Épitope
    • 16
    • 13
    • 9
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivité
    • 167
    • 61
    • 55
    • 29
    • 27
    • 26
    • 26
    • 21
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 92
    • 82
    • 4
    • 1
    Lapin
    Clonalité
    • 100
    • 79
    Polyclonal
    Conjugué
    • 92
    • 15
    • 13
    • 8
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NGFR est non-conjugé
    Application
    • 108
    • 87
    • 62
    • 58
    • 49
    • 30
    • 27
    • 21
    • 21
    • 14
    • 14
    • 12
    • 9
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for p75NTR.
     Réactivité croisée
    Humain, Souris, Rat
    Réactivité croisée (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogène
    A synthetic peptide from the extracellular domain of human p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in many other species including mouse and rat.
    Isotype
    IgG
    Top Product
    Discover our top product NGFR Anticorps primaire
  • Indications d'application
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Conseil sur la manipulation
    Avoid freeze and thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Date de péremption
    12 months
  • Antigène
    NGFR (Nerve Growth Factor Receptor (NGFR))
    Autre désignation
    p75NTR (NGFR Produits)
    Synonymes
    anticorps ngfr, anticorps wu:fb38c02, anticorps wu:fc10h01, anticorps CD271, anticorps Gp80-LNGFR, anticorps TNFRSF16, anticorps p75(NTR), anticorps p75NTR, anticorps LNGFR, anticorps RNNGFRR, anticorps Tnfrsf16, anticorps p75, anticorps NRH1b, anticorps fullback, anticorps nrh1, anticorps p75ntr, anticorps tnfrsf16, anticorps p75NGFR, anticorps nerve growth factor receptor, anticorps neurotrophin receptor associated death domain, anticorps nerve growth factor receptor S homeolog, anticorps nerve growth factor receptor (TNFR superfamily, member 16), anticorps NGFR, anticorps nradd, anticorps Ngfr, anticorps ngfr.S
    Sujet
    FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/<||a href="http://www.osenses.com/bex-family-c-21_106.html">BEX3<||/a>. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with <||a href="http://www.osenses.com/advanced_search_result.php?antigen=sqstm1&x=0&y=0">SQSTM1<||/a> which bridges NGFR to NTRK1. Interacts with <||a href="http://www.osenses.com/bex-family-c-21_106.html">BEX1<||/a>. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein.,Neurotrophic Receptors,Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR
    UniProt
    P08138
    Pathways
    Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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