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TRPV4 anticorps (Cytoplasmic Loop)

TRPV4 Reactivité: Souris WB, IHC Hôte: Mouton Polyclonal unconjugated
N° du produit ABIN351284
  • Antigène Voir toutes TRPV4 Anticorps
    TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
    Épitope
    • 16
    • 14
    • 9
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Loop
    Reactivité
    • 62
    • 25
    • 25
    • 22
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 62
    • 1
    • 1
    • 1
    Mouton
    Clonalité
    • 64
    • 1
    Polyclonal
    Conjugué
    • 31
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TRPV4 est non-conjugé
    Application
    • 50
    • 25
    • 17
    • 13
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for TRPV4.
     Réactivité croisée
    Humain, Souris, Rat
    Réactivité croisée (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogène
    A synthetic peptide from the 1t cytoplasmic loop of mouse TRPV4 conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat and human.
    Isotype
    IgG
    Top Product
    Discover our top product TRPV4 Anticorps primaire
  • Indications d'application
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Conseil sur la manipulation
    Avoid freeze and thaw cycles.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Date de péremption
    12 months
  • Antigène
    TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
    Autre désignation
    TRPV4 (TRPV4 Produits)
    Synonymes
    anticorps wu:fp52e02, anticorps CMT2C, anticorps HMSN2C, anticorps OTRPC4, anticorps SMAL, anticorps SPSMA, anticorps SSQTL1, anticorps TRP12, anticorps VRL2, anticorps VROAC, anticorps 0610033B08Rik, anticorps Trp12, anticorps VR-OAC, anticorps VRL-2, anticorps Otrpc4, anticorps Vroac, anticorps transient receptor potential cation channel, subfamily V, member 4, anticorps transient receptor potential cation channel subfamily V member 4, anticorps trpv4, anticorps TRPV4, anticorps Trpv4
    Sujet
    TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure. FUNCTION: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH , citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. SUBUNIT: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 3 ANK repeats.,Mammalian TRPV,Transient receptor potential cation channel subfamily V member 4, TrpV4, osm-9-like TRP channel 4, OTRPC4, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel, VR-OAC, Transient receptor potential protein 12, TRP12, Trp12, VRL-2, VROAC, OTRPC4, VR-OAC, MGC150050, 0610033B08Rik, Trp12, Vrl2, Vroac
    UniProt
    Q9EPK8
    Pathways
    Hormone Transport, Cell-Cell Junction Organization
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