SULT1A1 anticorps (Middle Region)

N° du produit ABIN357812

Détail du produit anti-SULT1A1 anticorps

Antigène: SULT1A1 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 1 (SULT1A1))

Épitope: Middle Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SULT1A1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects SULT1A1 (Center).

Purification: Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human SULT1A1.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western Blot: 1/100-1/500.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur SULT1A1

Antigène: SULT1A1 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 1 (SULT1A1))

Autre désignation: SULT1A1 (SULT1A1 Produits)

Synonymes: anticorps HAST1/HAST2, anticorps P-PST, anticorps PST, anticorps ST1A1, anticorps ST1A3, anticorps STP, anticorps STP1, anticorps TSPST1, anticorps AI266890, anticorps Stp, anticorps Stp1, anticorps ASTIV, anticorps Mx-ST, anticorps PST-1, anticorps St1a1, anticorps Stm, anticorps Sult1a3, anticorps pst, anticorps st1a3, anticorps stp, anticorps stp1, anticorps tspst1, anticorps cSULT1A1, anticorps SULT1A2, anticorps SULT1A1, anticorps SIAT8-D, anticorps ST8SiaIV, anticorps Siat8d, anticorps PST1, anticorps SIAT8D, anticorps ST8SIA-IV, anticorps sulfotransferase family 1A member 1, anticorps sulfotransferase family 1A, phenol-preferring, member 1, anticorps sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, anticorps sulfotransferase family 1A member 1 S homeolog, anticorps sulfotransferase 1A1, anticorps ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4, anticorps SULT1A1, anticorps Sult1a1, anticorps sult1a1, anticorps sult1a1.S, anticorps LOC704658, anticorps LOC709318, anticorps St8sia4, anticorps ST8SIA4, anticorps LOC100064221

Sujet: Sulphation is a significant detoxification pathway for diverse xenobiotics, yet this modification also plays an important role in the metabolism and bioactivation of many dietary and environmental mutagens, including heterocyclic amines implicated in the pathogenesis of several cancers. A major human sulfotransferase, SULT1A1, metabolizes and/or bioactivates many endogenous compounds and is implicated in a range of cancers because of its ability to transform xenobiotics to cellular mutagens and carcinogens. Genetic polymorphisms in human sulfotransferase 1A1 SULT1A1 have a major impact on SULT1A1 enzyme activity and affect the risk for cancer development in humans. A G--->A transition at codon 213 (CGC/Arg to CAC/His) of the SULT1A1 gene has been identified (SULT1A1*2), and individuals homozygous for the His allele have a markedly lower activity and stability of this enzyme than those with the high activity SULT1A1*1 allozyme, which has been associated with protection against dietary toxins and reduced susceptibility to colorectal and breast cancers.There is an increasing incidence of SULT1A1*1 homozygosity and decreasing incidence of SULT1A1*2 homozygosity with increasing age, indicating a potential association of SULT1A1*1 allozyme(s) with protection against cell and/or tissue damage during aging. CLN3, the locus for Batten disease, maps to the same region 16p12.1-p11.2 as SULT12A1, making SULT1A1 a candidate gene for this disorder.Synonyms: Aryl sulfotransferase 1, HAST1/HAST2, Phenol sulfotransferase 1, Phenol-sulfating phenol sulfotransferase 1, ST1A1, ST1A3, STP1, Sulfotransferase 1A1, Thermostable phenol sulfotransferase

Poids moléculaire: 34197 Da

ID gène: 6817

NCBI Accession: NP_803566

UniProt: P50225