PTPRA anticorps (N-Term)

N° du produit ABIN360736

Détail du produit anti-PTPRA anticorps

Antigène: PTPRA (Protein tyrosine Phosphatase, Receptor Type, A (PTPRA))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPRA est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to PTPalpha.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PTPalpha.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur PTPRA

Antigène: PTPRA (Protein tyrosine Phosphatase, Receptor Type, A (PTPRA))

Autre désignation: PTPRA (PTPRA Produits)

Synonymes: anticorps PTPRA, anticorps heptp, anticorps hlpr, anticorps hptpa, anticorps hptpalpha, anticorps lrp, anticorps ptpa, anticorps ptprl2, anticorps r-ptp-alpha, anticorps rptpa, anticorps HEPTP, anticorps HLPR, anticorps HPTPA, anticorps HPTPalpha, anticorps LRP, anticorps PTPA, anticorps PTPRL2, anticorps R-PTP-alpha, anticorps RPTPA, anticorps Ptpa, anticorps Ptpalpha, anticorps Rptpalpha, anticorps Rptra, anticorps Rptralpha, anticorps RPTP[a], anticorps zf-RPTP[a], anticorps ptpa-a, anticorps protein tyrosine phosphatase, receptor type A, anticorps protein tyrosine phosphatase, receptor type, A, anticorps protein tyrosine phosphatase, receptor type A S homeolog, anticorps PTPRA, anticorps ptpra, anticorps Ptpra, anticorps ptpra.S

Sujet: Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ? it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.Synonyms: PTP alpha, PTPA, PTPRL2, Protein-tyrosine phosphatase alpha, R-PTP-alpha, Receptor-type tyrosine-protein phosphatase alpha

ID gène: 5786, 9606

UniProt: P18433