TUBB3 anticorps

N° du produit ABIN361368

Détail du produit anti-TUBB3 anticorps

Antigène: TUBB3 (Tubulin, beta 3 (TUBB3))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TUBB3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for the ~55kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1. It is expected that this antibody will have wide species cross reactivity.

Réactivité croisée: Rat (Rattus)

Purification: Protein G purified culture supernatant

Immunogène: Synthetic peptide corresponding to amino acid residues specific to beta III tubulin conjugated to KLH

Clone: AA10

Isotype: IgG

Information d'application

Indications d'application: Recommended Dilution: WB: 1:10,000 IHC: 1:1,000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-TUBB3 (ABIN361368)

Moldovan, Al-Ebraheem, Lobo, Park, Farquharson, Bock: "Altered transition metal homeostasis in the cuprizone model of demyelination." dans: Neurotoxicology, Vol. 48, pp. 1-8, (2015) (PubMed).

Stallings, Puttaparthi, Dowling, Luther, Burns, Davis, Elliott: "TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis." dans: PLoS ONE, Vol. 8, Issue 8, pp. e71793, (2014) (PubMed).

Détails sur TUBB3

Antigène: TUBB3 (Tubulin, beta 3 (TUBB3))

Autre désignation: TUBB3 (TUBB3 Produits)

Synonymes: anticorps CDCBM, anticorps CFEOM3A, anticorps TUBB4, anticorps beta-4, anticorps TUBB3, anticorps 3200002H15Rik, anticorps M(beta)3, anticorps M(beta)6, anticorps tubb3, anticorps tubulin beta 3 class III, anticorps tubulin, beta 3 class III, anticorps tubulin beta 3 class III L homeolog, anticorps beta-tubulin 3, anticorps tubulin beta-3 chain, anticorps beta tubulin 3, anticorps TUBB3, anticorps Tubb3, anticorps tubb3, anticorps tubb3.L, anticorps LOC100581245, anticorps tub3

Sujet: Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003) Anti-Beta III Tubulin Western blot of rat cortex lysate showing specific immunolabeling of the ~55k beta III tubulin protein.

Poids moléculaire: '55 kDa

ID gène: 246118

UniProt: Q4QRB4

Pathways: Dynamique des Microtubules, M Phase