KCNC1 anticorps (pSer503)

N° du produit ABIN361488

Détail du produit anti-KCNC1 anticorps

Antigène: KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))

Épitope: pSer503

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for the ~100k Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.

Réactivité croisée: Souris, Rat (Rattus)

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-KCNC1 (ABIN361488)

Sagi, Medrihan, George, Barney, McCabe, Greengard: "Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action." dans: Molecular psychiatry, Vol. 25, Issue 6, pp. 1191-1201, (2020) (PubMed).

Détails sur KCNC1

Antigène: KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))

Autre désignation: KCNC1 (KCNC1 Produits)

Synonymes: anticorps kv3.1, anticorps C230009H10Rik, anticorps KShIIIB, anticorps KV4, anticorps Kcr2-1, anticorps Kv3.1, anticorps NGK2, anticorps Shaw, anticorps Kv4, anticorps NGK2-KV4, anticorps KV3.1, anticorps KCNC2, anticorps zgc:194940, anticorps zgc:194950, anticorps potassium voltage-gated channel subfamily C member 1, anticorps potassium voltage-gated channel, Shaw-related subfamily, member 1, anticorps potassium voltage gated channel, Shaw-related subfamily, member 1, anticorps potassium voltage-gated channel, Shaw-related subfamily, member 1a, anticorps KCNC1, anticorps kcnc1, anticorps Kcnc1, anticorps kcnc1a

Sujet: Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995, Pongs, 1999, Blaine and Ribera, 1998, Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Poids moléculaire: '100 kDa

ID gène: 25327

UniProt: P25122