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IFNAR1 anticorps (pSer535, pSer539)

IFNAR1 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361505
  • Antigène Voir toutes IFNAR1 Anticorps
    IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
    Épitope
    • 21
    • 16
    • 13
    • 9
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer535, pSer539
    Reactivité
    • 87
    • 29
    • 25
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 80
    • 22
    • 1
    Lapin
    Clonalité
    • 71
    • 31
    • 1
    Polyclonal
    Conjugué
    • 51
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp IFNAR1 est non-conjugé
    Application
    • 46
    • 30
    • 27
    • 26
    • 24
    • 24
    • 10
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for IFNAR1 protein phosphorylated at Ser535,539.
     Réactivité croisée
    Humain
    Homologie
    bovine, canine, mouse, non-human primate, rat, sheep
    Purification
    Antigen Affinity Purified from Pooled Serum
    Immunogène
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 conjugated to KLH
    Top Product
    Discover our top product IFNAR1 Anticorps primaire
  • Indications d'application
    Recommended Dilution: WB: 1:1000 IHC: 1:1000 Quality Control: Western blots performed on each lot.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Stock
    -20 °C
  • Bhattacharya, HuangFu, Liu, Veeranki, Baker, Koumenis, Diehl, Fuchs: "Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor." dans: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2318-25, (2010) (PubMed).

    Kumar, Krolewski, Fuchs: "Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor." dans: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46614-20, (2004) (PubMed).

  • Antigène
    IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
    Autre désignation
    IFNAR1 (IFNAR1 Produits)
    Synonymes
    anticorps ifnar1, anticorps IFNAR1, anticorps CD118, anticorps Ifar, anticorps Ifnar, anticorps Ifrc, anticorps Infar, anticorps AVP, anticorps IFN-alpha-REC, anticorps IFNAR, anticorps IFNBR, anticorps IFRC, anticorps IFN-R-1, anticorps interferon alpha and beta receptor subunit 1, anticorps interferon-alpha/beta receptor alpha chain-like, anticorps interferon (alpha and beta) receptor 1, anticorps interferon alpha/beta receptor 1, anticorps IFNAR1, anticorps ifnar1, anticorps Ifnar1, anticorps LOC609830
    Sujet
    Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-a Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003). Anti-Phospho Ser535,539 IFNAR1 Western blot of immunoprecipitates from HEK 293 cells transfected with 1. Mock, 2. IFNAR1 WT, and 3. IFNAR1 S535A and S539A mutants showing specific immunolabeling of the ~110k to ~130k IFNAR1 WT. The immunolabeling is absent in IFNAR1 Ser535 and Ser539 mutants (Control). The immunolabeling is blocked by the phosphopeptide (Phos) used as the antigen but not by the corresponding dephosphopeptide (Dephos).
    Poids moléculaire
    110-130 kDa
    ID gène
    3654
    UniProt
    P17181
    Pathways
    Signalistation JAK/STAT, Hepatitis C
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