KCNC1 anticorps (pSer503)

N° du produit ABIN372706

Détail du produit anti-KCNC1 anticorps

Antigène: KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))

Épitope: pSer503

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNC1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB)

Specificité: This antibody recognizes the ~100k KCNC1 (Kv3.1) protein phosphorylated at Ser503 in Rat brain extracts.

Réactivité croisée (Details): Species reactivity (tested):Rat and Mouse.

Purification: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of KCNC1 conjugated to keyhole limpet hemocyanin (KLH).

Isotype: IgG

Information d'application

Indications d'application: Dot Blot: 1/1000. Western blot: 1/1000. Immunohistochemistry on Frozen Sections: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Références pour anticorps anti-KCNC1 (ABIN372706)

Ahmed, Spikings, Zhou, Thompsett, Zhang: "Pre-hybridisation: an efficient way of suppressing endogenous biotin-binding activity inherent to biotin-streptavidin detection system." dans: Journal of immunological methods, Vol. 406, pp. 143-7, (2014) (PubMed).

Gupta, Palmer, Spence, Hudson, Stephens: "Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport." dans: Traffic (Copenhagen, Denmark), Vol. 9, Issue 11, pp. 1850-66, (2008) (PubMed).

Chernova, Steinert, Guerin, Nicotera, Forsythe, Smith: "Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 32, pp. 8475-85, (2007) (PubMed).

Détails sur KCNC1

Antigène: KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))

Autre désignation: KCNC1 (KCNC1 Produits)

Synonymes: anticorps kv3.1, anticorps C230009H10Rik, anticorps KShIIIB, anticorps KV4, anticorps Kcr2-1, anticorps Kv3.1, anticorps NGK2, anticorps Shaw, anticorps Kv4, anticorps NGK2-KV4, anticorps KV3.1, anticorps KCNC2, anticorps zgc:194940, anticorps zgc:194950, anticorps potassium voltage-gated channel subfamily C member 1, anticorps potassium voltage-gated channel, Shaw-related subfamily, member 1, anticorps potassium voltage gated channel, Shaw-related subfamily, member 1, anticorps potassium voltage-gated channel, Shaw-related subfamily, member 1a, anticorps KCNC1, anticorps kcnc1, anticorps Kcnc1, anticorps kcnc1a

Sujet: Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995, Pongs, 1999, Blaine and Ribera, 1998, Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).Synonyms: Kv4, NGK2, Potassium voltage-gated channel subfamily C member 1, Voltage-gated potassium channel subunit Kv3.1

ID gène: 25327

NCBI Accession: NP_036988

UniProt: P25122