PAX8 anticorps (N-Term)

N° du produit ABIN374237

Détail du produit anti-PAX8 anticorps

Antigène: PAX8 (Paired Box 8 (PAX8))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PAX8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Séquence: PHNSIRSGHG GLN-C

Specificité: This antibody is expected to recognise all five isoforms of Human PAX8.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide from N Terminus of the protein sequence according to NP_003457.1, NP_039245.1, NP_039246.1, NP_039247.1, NP_054698.1. Genename: PAX8

Information d'application

Indications d'application: Peptide ELISA: Antibody Detection Limit Dilution 1/32000. Immunohistochemistry: 1-2 μg/mL. In paraffin embedded Human Thyroid Gland shows nuclear staining in epithelial cellsaround follicles. A customer found this antibody unsuccessful in Immunohistochemistry onMouse tissues.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.

Références pour anticorps anti-PAX8 (ABIN374237)

Borgogni, Sarchielli, Sottili, Santarlasci, Cosmi, Gelmini, Lombardi, Cantini, Perigli, Luconi, Vannelli, Annunziato, Adorini, Serio, Crescioli: "Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells." dans: Endocrinology, Vol. 149, Issue 7, pp. 3626-34, (2008) (PubMed).

Détails sur PAX8

Antigène: PAX8 (Paired Box 8 (PAX8))

Autre désignation: PAX8 (PAX8 Produits)

Synonymes: anticorps PAX8, anticorps XPax-8, anticorps XPax8, anticorps pax-8, anticorps PAX-8, anticorps Pax-8, anticorps paired box 8, anticorps paired box 8 L homeolog, anticorps PAX8, anticorps pax8, anticorps Pax8, anticorps pax8.L

Sujet: This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells.Synonyms: Paired box protein Pax-8, Pax-8

ID gène: 7849

NCBI Accession: NP_003457

UniProt: Q06710

Pathways: Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation