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APBA1 anticorps (Internal Region)

APBA1 Reactivité: Humain, Souris, Rat WB Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN374796
  • Antigène Voir toutes APBA1 Anticorps
    APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))
    Épitope
    • 15
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 25
    • 1
    Chèvre
    Clonalité
    • 26
    Polyclonal
    Conjugué
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp APBA1 est non-conjugé
    Application
    • 24
    • 13
    • 13
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    C-EASHPSQDGK RQYK
    Specificité
    This antibody detects APBA1 / MINT1.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat.
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogène
    Peptide from the internal region of the protein sequence according to NP_001154.2. Genename: APBA1
    Top Product
    Discover our top product APBA1 Anticorps primaire
  • Indications d'application
    Peptide ELISA: Detection Limit: 1/16000. Western blot: 0.1-0.3 μg/mL. Approx 100 kDa band observed in Human Brain (Cerebellumand Hippocampus) lysates (calculated MW of 92.0 kDa according to NP_001154.2).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))
    Autre désignation
    APBA1 / MINT1 (APBA1 Produits)
    Synonymes
    anticorps APBA1, anticorps 6430513E09Rik, anticorps Lin-10, anticorps Mint, anticorps Mint1, anticorps Urop11, anticorps X11, anticorps X11alpha, anticorps D9S411E, anticorps LIN10, anticorps MINT1, anticorps X11A, anticorps X11ALPHA, anticorps amyloid beta precursor protein binding family A member 1, anticorps amyloid beta (A4) precursor protein-binding, family A, member 1b, anticorps ketopantoate reductase, anticorps 2-dehydropantoate 2-reductase, anticorps amyloid beta (A4) precursor protein-binding, family A, member 1 (X11), anticorps amyloid beta (A4) precursor protein-binding, family A, member 1, anticorps amyloid beta (A4) precursor protein binding, family A, member 1, anticorps APBA1, anticorps apba1b, anticorps apbA1, anticorps apba1, anticorps Apba1
    Sujet
    APBA1 is part of two multimeric complexes, the first containing Munc18-1 and syntaxin 1 and the second being a brain specific heterotrimeric complex with LIN-10/X11-alpha, LIN-2/CASK, and LIN7. It binds to the cytoplasmic domain of amyloid protein (APP). ABPA1 has a putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. It may modulate processing of the beta amyloid precursor protein (APP) and hence formation of beta APP. The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three Mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.Synonyms: Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Neuron-specific X11 protein, Neuronal Munc18-1-interacting protein 1
    ID gène
    320, 9606
    UniProt
    Q02410
    Pathways
    Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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