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Granulin anticorps (Internal Region)

GRN Reactivité: Humain WB Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN375134
  • Antigène Voir toutes Granulin (GRN) Anticorps
    Granulin (GRN)
    Épitope
    • 15
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 51
    • 9
    • 4
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 42
    • 9
    • 5
    • 2
    • 1
    Chèvre
    Clonalité
    • 48
    • 11
    Polyclonal
    Conjugué
    • 35
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Granulin est non-conjugé
    Application
    • 52
    • 19
    • 17
    • 13
    • 13
    • 10
    • 7
    • 7
    • 6
    • 3
    • 3
    Western Blotting (WB)
    Specificité
    This antibody recognizes Granulin / GRN.
    Réactivité croisée (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography
    Immunogène
    Peptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1.
    Top Product
    Discover our top product GRN Anticorps primaire
  • Indications d'application
    Peptide ELISA: 1/8000. Western Blot: 1 - 3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    Granulin (GRN)
    Autre désignation
    Granulins (GRN) (GRN Produits)
    Synonymes
    anticorps GRN, anticorps grn, anticorps wu:fb11g12, anticorps wu:fj18f05, anticorps MGC53354, anticorps DKFZp459H066, anticorps CLN11, anticorps GEP, anticorps GP88, anticorps PCDGF, anticorps PEPI, anticorps PGRN, anticorps epithelin, anticorps acrogranin, anticorps granulin precursor, anticorps granulin a, anticorps Granulins, anticorps granulin L homeolog, anticorps granulin, anticorps GRN, anticorps grna, anticorps grn, anticorps grn.L, anticorps granulin, anticorps ORF1 granulin, anticorps Grn
    Classe de substances
    Viral Protein
    Sujet
    Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. Involvement in disease: Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485], also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.Synonyms: GRN, Granulins, PEPI, Proepithelin
    Poids moléculaire
    63.5 kDa (NP_002078.1)
    ID gène
    2896, 9606
    UniProt
    P28799
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