FADD anticorps

N° du produit ABIN377014

Détail du produit anti-FADD anticorps

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FADD est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Specificité: Human FADD

Attributs du produit: Mouse Anti-Human FADD-UNLB

Purification: Purified

Immunogène: Recombinant FADD

Clone: 1A11

Isotype: IgG1

Information d'application

Indications d'application:

• Applications: ELISA - Quality tested WB - Quality tested IP - Quality tested
• Working Dilutions: ELISA Purified (UNLB) antibody 0.5 g/mL Immunoblotting HRP conjugate 1:4,000 - 1:8,000 Immunoprecipitation SEPH conjugate 40 L

Volume d'échantillon: 0,2 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur FADD

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Autre désignation: FADD (FADD Produits)

Synonymes: anticorps MORT1, anticorps Mort1/FADD, anticorps Mort1, anticorps TNFRSF6, anticorps adaptor, anticorps fadd, anticorps mort1, anticorps xfadd, anticorps Fas associated via death domain, anticorps Fas (TNFRSF6)-associated via death domain, anticorps Fas associated via death domain S homeolog, anticorps Fas (tnfrsf6)-associated via death domain, anticorps FADD, anticorps Fadd, anticorps fadd.S, anticorps fadd

Sujet: Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1 β -converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.

Pathways: Apoptose, Signalisation TLR, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades