MLH1 anticorps

N° du produit ABIN379237

Détail du produit anti-MLH1 anticorps

Antigène: MLH1 (MutL Homolog 1 (MLH1))

Reactivité: Humain, Rat, Hamster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MLH1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: The G168-15 antibody recognizes the human and mouse MLH1 (80-85  kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. cross reacts with human, hamster and rat

Immunogène: Full length recombinant MLH.

Type of Immunogen: Recombinant protein

Clone: G168-15

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid containing sodium azide as a preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur MLH1

Antigène: MLH1 (MutL Homolog 1 (MLH1))

Autre désignation: MLH1 (MLH1 Produits)

Synonymes: anticorps CG11482, anticorps Dmel\\CG11482, anticorps dmlh-1, anticorps dmlh1, anticorps zgc:66301, anticorps MLH1, anticorps LOC100232198, anticorps 1110035C23Rik, anticorps AI317206, anticorps AI325952, anticorps AI561766, anticorps COCA2, anticorps FCC2, anticorps HNPCC, anticorps HNPCC2, anticorps hMLH1, anticorps mutL homolog 1, anticorps CG11482 gene product from transcript CG11482-RB, anticorps mutL homolog 1 S homeolog, anticorps mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), anticorps DNA mismatch repair protein Mlh1, anticorps MLH1, anticorps Mlh1, anticorps mlh1.S, anticorps mlh1, anticorps LOC588545

Sujet: Name/Gene ID: MLH1

Synonyms: MLH1, COCA2, FCC2, HMLH1, HNPCC, HNPCC2, MutL protein homolog 1

ID gène: 4292

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response