Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) anticorps

Détails pour le produit réf. ABIN389205, Fournisseur: Connectez-vous pour afficher
Antigène
  • AR
  • akr1b7
  • ALR1
  • Akr1a4
  • 2610201A18Rik
  • ADR
  • ALDR1
  • ALR2
  • zgc:86611
  • ALDRED
  • ALR-P-I
  • Akr1b3
  • Akr1b4
  • Aldr1
  • Alr
  • RATALDRED
  • Ahr-1
  • Ahr1
  • Akr1b1
  • Aldor1
  • aldo-keto reductase family 1 member B
  • aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog
  • aldo-keto reductase family 1 member E2
  • aldo-keto reductase family 1 member A1
  • aldo-keto reductase family 1, member A1 (aldehyde reductase)
  • aldo-keto reductase family 1, member B1 (aldose reductase)
  • aldo-keto reductase family 1, member B3 (aldose reductase)
  • AKR1B1
  • akr1b1.S
  • AKR1E2
  • AKR1A1
  • Akr1a1
  • akr1b1
  • Akr1b1
  • Akr1b3
Épitope
AA 290-316, C-Term
28
16
6
6
6
4
3
3
3
2
2
1
1
1
1
1
1
1
1
Reactivité
Humain
117
52
51
7
5
4
3
3
3
3
3
1
1
Hôte
Lapin
98
21
4
Clonalité (Clone)
Polyclonal ()
Conjugué
Inconjugué
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
93
42
41
26
25
13
12
9
6
4
3
2
1
Options
Fournisseur
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Supplier Product No.
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Immunogène This AKR1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-316 AA from the C-terminal region of human AKR1B1.
Clone RB14692
Isotype Ig Fraction
Specificité This AKR1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287~316 amino acids from the C-terminal region of human AKR1B1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Autre désignation AKR1B1 (AKR1B1 Antibody Extrait)
Sujet AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.
Synonyms: Aldose reductase, AR, Aldehyde reductase, AKR1B1
Pathways: Pyruvate metabolism, Glycerolipid metabolism, Fructose and mannose metabolism, Galactose metabolism
Poids moléculaire 35853 Da
ID gène 231
UniProt P15121
Domaine de recherche Stem Cells, Metabolism, Cell Structure
Pathways Metabolism of Steroid Hormones and Vitamin D, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process
Indications d'application WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) antibody (ABIN389205) Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AKR1B1...
Western Blotting (WB) image for anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) antibody (ABIN389205) Western blot analysis of anti-AKR1B1 Pab (ABIN389205) in A375 cell line lysates (35 µ...
Western Blotting (WB) image for anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) antibody (ABIN389205) Western blot analysis of AKR1B1 (arrow) using rabbit polyclonal AKR1B1 Antibody (C-te...
Produit citée dans: Guo, Wang, Liu, Myatt, Sun: "Induction of PGF2? synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts." dans: Endocrinology, Vol. 155, Issue 8, pp. 3017-24, 2014 (PubMed).

Background publications Steuber, Heine, Podjarny, Klebe: "Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features." dans: Journal of molecular biology, Vol. 379, Issue 5, pp. 991-1016, 2008 (PubMed).

Gleissner, Sanders, Nadler, Ley: "Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 6, pp. 1137-43, 2008 (PubMed).

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