Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) anticorps

Détails pour le produit réf. ABIN389205, Fournisseur: Connectez-vous pour afficher
Antigène
  • ADR
  • ALDR1
  • ALR2
  • AR
  • Ahr-1
  • Ahr1
  • Akr1b1
  • Aldor1
  • Aldr1
  • ALDRED
  • ALR-P-I
  • Akr1b3
  • Akr1b4
  • Alr
  • RATALDRED
  • akr1b7
  • zgc:86611
  • aldo-keto reductase family 1 member B
  • aldo-keto reductase family 1, member B3 (aldose reductase)
  • aldo-keto reductase family 1, member B1 (aldose reductase)
  • aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog
  • AKR1B1
  • Akr1b3
  • Akr1b1
  • akr1b1.S
  • akr1b1
Épitope
AA 290-316, C-Term
28
18
7
6
5
4
3
3
3
3
2
2
1
1
1
1
1
1
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1
Reactivité
Humain
136
57
56
7
5
4
3
3
3
3
3
1
1
Hôte
Lapin
116
21
5
Clonalité (Clone)
Polyclonal ()
Conjugué
Inconjugué
5
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
112
58
54
31
31
13
12
9
6
5
4
3
2
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène This AKR1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-316 AA from the C-terminal region of human AKR1B1.
Clone RB14692
Isotype Ig Fraction
Specificité This AKR1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287~316 amino acids from the C-terminal region of human AKR1B1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Autre désignation AKR1B1 (AKR1B1 Antibody Extrait)
Sujet AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.
Synonyms: Aldose reductase, AR, Aldehyde reductase, AKR1B1
Pathways: Pyruvate metabolism, Glycerolipid metabolism, Fructose and mannose metabolism, Galactose metabolism
Poids moléculaire 35853 Da
ID gène 231
UniProt P15121
Pathways Metabolism of Steroid Hormones and Vitamin D, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process
Indications d'application WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption 6 months
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) antibody (ABIN389205) Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AKR1B1...
Western Blotting (WB) image for anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) antibody (ABIN389205) Western blot analysis of anti-AKR1B1 Pab (ABIN389205) in A375 cell line lysates (35 µ...
Western Blotting (WB) image for anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) antibody (ABIN389205) Western blot analysis of AKR1B1 (arrow) using rabbit polyclonal AKR1B1 Antibody (C-te...
Produit citée dans: Guo, Wang, Liu, Myatt, Sun: "Induction of PGF2? synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts." dans: Endocrinology, Vol. 155, Issue 8, pp. 3017-24, 2014 (PubMed).

Background publications Steuber, Heine, Podjarny, Klebe: "Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features." dans: Journal of molecular biology, Vol. 379, Issue 5, pp. 991-1016, 2008 (PubMed).

Gleissner, Sanders, Nadler, Ley: "Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 6, pp. 1137-43, 2008 (PubMed).

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