Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) (AA 407-438), (Center), (Val422) anticorps

Détails pour le produit réf. ABIN390129, Fournisseur: Connectez-vous pour afficher
Antigène
  • fc39c11
  • wu:fc39c11
  • zgc:110210
  • AF9
  • YEATS3
  • 2210011H10Rik
  • 2610012I03Rik
  • 3830408D16Rik
  • Af9
  • D4Ertd321e
  • Af-9
  • MLLT3, super elongation complex subunit
  • myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
  • mllt3
  • MLLT3
  • Mllt3
Épitope
AA 407-438, Center, Val422
29
11
8
7
7
6
4
3
3
3
2
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris
88
19
10
7
7
6
6
4
3
2
2
1
Hôte
Lapin
85
3
Clonalité (Clone)
Polyclonal ()
Conjugué
Inconjugué
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
78
43
35
32
21
17
5
4
2
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène This AF9 (MLLT3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-438 AA from the Central region of human AF9 (MLLT3).
Clone RB6799
Isotype Ig Fraction
Specificité This AF9 (MLLT3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human MLLT3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Antigène
Autre désignation AF9 (MLLT3) (MLLT3 Antibody Extrait)
Sujet The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9,11)(p22,q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified, BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.
Synonyms: ALL1 fused gene from chromosome 9 protein, Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein,
Poids moléculaire 63367 DA
ID gène 4300
UniProt P42568
Indications d'application WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption 6 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) (AA 407-438), (Center), (Val422) antibody (ABIN390129) The anti-MLLT3 Pab (ABIN390129) is used in Western blot to detect MLLT3 in mouse cere...
Western Blotting (WB) image for anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) (AA 407-438), (Center), (Val422) antibody (ABIN390129) MLLT3 Antibody (C-term) (ABIN390129) western blot analysis in 293 cell line lysates (...
Background publications Strissel, Strick, Tomek, Roe, Rowley, Zeleznik-Le: "DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis." dans: Human molecular genetics, Vol. 9, Issue 11, pp. 1671-9, 2000 (PubMed).

Iida, Seto, Yamamoto, Komatsu, Tojo, Asano, Kamada, Ariyoshi, Takahashi, Ueda: "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13." dans: Oncogene, Vol. 8, Issue 11, pp. 3085-92, 1993 (PubMed).

Nakamura, Alder, Gu, Prasad, Canaani, Kamada, Gale, Lange, Crist, Nowell: "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 10, pp. 4631-5, 1993 (PubMed).

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