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Neuregulin 1 anticorps (AA 198-229)

NRG1 Reactivité: Humain FACS, IHC (p) Hôte: Lapin Polyclonal RB01275-01276 unconjugated
N° du produit ABIN390160
  • Antigène Voir toutes Neuregulin 1 (NRG1) Anticorps
    Neuregulin 1 (NRG1)
    Épitope
    • 16
    • 16
    • 15
    • 10
    • 10
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 198-229
    Reactivité
    • 103
    • 77
    • 53
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 121
    • 10
    Lapin
    Clonalité
    • 121
    • 10
    Polyclonal
    Conjugué
    • 58
    • 13
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Cet anticorp Neuregulin 1 est non-conjugé
    Application
    • 93
    • 43
    • 39
    • 39
    • 39
    • 37
    • 24
    • 14
    • 12
    • 11
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This NRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-229 amino acids from the Central region of human NRG1.
    Clone
    RB01275-01276
    Isotype
    Ig Fraction
    Top Product
    Discover our top product NRG1 Anticorps primaire
  • Indications d'application
    IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Mondal, Schilling, Folger, Steibel, Buchnick, Zalman, Ireland, Meidan, Smith: "Deciphering the luteal transcriptome: potential mechanisms mediating stage-specific luteolytic response of the corpus luteum to prostaglandin F??." dans: Physiological genomics, Vol. 43, Issue 8, pp. 447-56, (2011) (PubMed).

  • Antigène
    Neuregulin 1 (NRG1)
    Autre désignation
    NRG1 (NRG1 Produits)
    Synonymes
    anticorps 6030402G23Rik, anticorps ARIA, anticorps D230005F13Rik, anticorps GGF, anticorps GGFII, anticorps HRG, anticorps HRGalpha, anticorps Hgl, anticorps NDF, anticorps SMDF, anticorps GGF2, anticorps HGL, anticorps HRG1, anticorps HRGA, anticorps MST131, anticorps NRG-1, anticorps heregulin, anticorps nrg1-A, anticorps pro-neuregulin-1, anticorps NRG1, anticorps wu:fm70e01, anticorps DKFZp459A1838, anticorps neuregulin 1, anticorps histidine rich glycoprotein, anticorps neuregulin 1 L homeolog, anticorps Nrg1, anticorps NRG1, anticorps HRG, anticorps nrg1.L, anticorps nrg1
    Sujet
    Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
    Poids moléculaire
    70392
    ID gène
    3084
    NCBI Accession
    NP_001153467, NP_001153471, NP_001153473, NP_001153477, NP_001153480, NP_039250, NP_039251, NP_039252, NP_039253, NP_039254, NP_039256, NP_039258
    UniProt
    Q02297
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
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