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APH1A anticorps (N-Term)

APH1A Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB4994 unconjugated
N° du produit ABIN390272
  • Antigène Voir toutes APH1A Anticorps
    APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
    Épitope
    • 16
    • 13
    • 8
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 77-109, N-Term
    Reactivité
    • 54
    • 35
    • 19
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 59
    • 1
    Lapin
    Clonalité
    • 60
    Polyclonal
    Conjugué
    • 20
    • 7
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp APH1A est non-conjugé
    Application
    • 51
    • 37
    • 14
    • 14
    • 13
    • 13
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This APH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-109 amino acids from the N-terminal region of human APH1.
    Clone
    RB4994
    Isotype
    Ig Fraction
    Top Product
    Discover our top product APH1A Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
    Autre désignation
    APH1 (APH1A Produits)
    Synonymes
    anticorps 6530402N02Rik, anticorps APH-1, anticorps APH-1A, anticorps CGI-78, anticorps RGD1311546, anticorps APH-1a, anticorps aph-1 homolog A, gamma-secretase subunit, anticorps aph-1 homolog A, gamma secretase subunit L homeolog, anticorps aph-1 homolog A, gamma secretase subunit, anticorps anterior pharynx defective 1 homolog A (C. elegans), anticorps aph1 homolog A, gamma secretase subunit, anticorps acylamino-acid-releasing enzyme-like, anticorps APH1A, anticorps aph1a.L, anticorps Aph1a, anticorps LOC100219182
    Sujet
    APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
    Poids moléculaire
    28996
    ID gène
    51107
    NCBI Accession
    NP_001071096, NP_001230700, NP_001230701, NP_057106
    UniProt
    Q96BI3
    Pathways
    Signalisation Notch, Neurotrophin Signaling Pathway
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