This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This PKA 2 beta (PRKAR2B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-62 amino acids from the N-terminal region of human PKA 2 beta (PRKAR2B).
anticorps MGC83177, anticorps PRKAR2B, anticorps AI451071, anticorps AW061005, anticorps PKARIIbeta, anticorps Pkarb2, anticorps RII(beta), anticorps RATDNA, anticorps PRKAR2, anticorps RII-BETA, anticorps protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog, anticorps protein kinase cAMP-dependent type II regulatory subunit beta, anticorps protein kinase, cAMP-dependent, regulatory, type II, beta, anticorps protein kinase, cAMP dependent regulatory, type II beta, anticorps protein kinase cAMP-dependent type 2 regulatory subunit beta, anticorps prkar2b.S, anticorps PRKAR2B, anticorps prkar2b, anticorps Prkar2b
Sujet
CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.