PGK1 anticorps (AA 117-145)

N° du produit ABIN391135

Détail du produit anti-PGK1 anticorps

Antigène: PGK1 (Phosphoglycerate Kinase 1 (PGK1))

Épitope: AA 117-145

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PGK1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Homologie: Hs, Pr, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PGK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-145 amino acids from the Central region of human PGK1.

Clone: RB05463

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:100. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PGK1 (ABIN391135)

Chen, Liu, Wu, Sheu: "Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1." dans: The American journal of Chinese medicine, Vol. 43, Issue 8, pp. 1671-96, (2016) (PubMed).

Ho, Morrison, Silva, Coomber: "The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression." dans: Bioscience reports, Vol. 36, Issue 1, pp. e00299, (2016) (PubMed).

Xu, Fang, Zhu, Dai, Nie, Chen, Qin, Wang, Wang, Qiao: "Cigarette smoking exposure alters pebp1 DNA methylation and protein profile involved in MAPK signaling pathway in mice testis." dans: Biology of reproduction, Vol. 89, Issue 6, pp. 142, (2013) (PubMed).

Danshina, Geyer, Dai, Goulding, Willis, Kitto, McCarrey, Eddy, OBrien: "Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice." dans: Biology of reproduction, Vol. 82, Issue 1, pp. 136-45, (2009) (PubMed).

Doran, OConnell, Gannon, Kavanagh, Ohlendieck: "Opposite pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis." dans: Proteomics, Vol. 8, Issue 2, pp. 364-77, (2008) (PubMed).

Kilic, Kasperczyk, Fulda, Debatin: "Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance." dans: Oncogene, Vol. 26, Issue 14, pp. 2027-38, (2007) (PubMed).

OConnell, Gannon, Doran, Ohlendieck: "Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle." dans: International journal of molecular medicine, Vol. 20, Issue 2, pp. 145-53, (2007) (PubMed).

West, Moore, Biskup, Bugayenko, Smith, Ross, Dawson, Dawson: "Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16842-7, (2005) (PubMed).

Détails sur PGK1

Antigène: PGK1 (Phosphoglycerate Kinase 1 (PGK1))

Autre désignation: PGK1 (PGK1 Produits)

Synonymes: anticorps MIG10, anticorps PGKA, anticorps Pgk-1, anticorps Pgk, anticorps PGK, anticorps wu:fd59b07, anticorps wu:fj36g06, anticorps zgc:56252, anticorps zgc:77899, anticorps PGK1, anticorps phosphoglycerate kinase 1, anticorps pgk2, anticorps pgka, anticorps phosphoglycerate kinase 1, anticorps phosphoglycerate kinase 1 L homeolog, anticorps PGK1, anticorps Pgk1, anticorps pgk1, anticorps LOC100348124, anticorps pgk1.L

Sujet: Also known as ATP:3-phosphoglycerate 1-phosphotransferase (EC 2.7.2.3), this major enzyme in glycolysis catalyzes the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate, generating one molecule of ATP. New blood vessel formation or angiogenesis is critical for tumor expansion and metastasis. Lay et al. (2000) showed that the plasmin reductase isolated from conditioned medium of fibrosarcoma cells is the glycolytic enzyme phosphoglycerate kinase. They concluded that phosphoglycerate kinase not only functions in glycolysis but is secreted by tumor cells and participates in the angiogenic process as a disulfide reductase.

Poids moléculaire: 44615

ID gène: 5230

NCBI Accession: NP_000282

UniProt: P00558

Pathways: Cellular Glucan Metabolic Process