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ACVR1C/ALK7 anticorps (N-Term)

ACVR1C Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB8195 unconjugated
N° du produit ABIN391157
  • Antigène Voir toutes ACVR1C/ALK7 (ACVR1C) Anticorps
    ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))
    Épitope
    • 16
    • 9
    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 33-62, N-Term
    Reactivité
    • 44
    • 43
    • 29
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 53
    • 5
    Lapin
    Clonalité
    • 55
    • 3
    Polyclonal
    Conjugué
    • 28
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ACVR1C/ALK7 est non-conjugé
    Application
    • 50
    • 25
    • 20
    • 13
    • 13
    • 11
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This Activin A Receptor Type IC (ACVR1C) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human Activin A Receptor Type IC (ACVR1C).
    Clone
    RB8195
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ACVR1C Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Liu, Yang, Li, Liu, Miao, Yang, Zou, Yuan: "Overexpression of B2M and loss of ALK7 expression are associated with invasion, metastasis, and poor-prognosis of the pancreatic ductal adenocarcinoma." dans: Cancer biomarkers : section A of Disease markers, Vol. 15, Issue 6, pp. 735-43, (2015) (PubMed).

  • Antigène
    ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))
    Autre désignation
    Activin A Receptor Type IC (ACVR1C) (ACVR1C Produits)
    Synonymes
    anticorps ACVRLK7, anticorps ALK7, anticorps Alk-7, anticorps C230097P10, anticorps Alk7, anticorps habrec1, anticorps activin A receptor type 1C, anticorps activin A receptor, type IC, anticorps ACVR1C, anticorps Acvr1c
    Sujet
    ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
    Poids moléculaire
    54871
    ID gène
    130399
    NCBI Accession
    NP_001104501, NP_001104502, NP_001104503, NP_660302
    UniProt
    Q8NER5
    Pathways
    Negative Regulation of Hormone Secretion, Positive Regulation of Endopeptidase Activity
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