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MARK1 anticorps (C-Term)

MARK1 Reactivité: Humain, Souris WB Hôte: Lapin Polyclonal RB8547 unconjugated
N° du produit ABIN391220
  • Antigène Voir toutes MARK1 Anticorps
    MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
    Épitope
    • 10
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 671-700, C-Term
    Reactivité
    • 62
    • 35
    • 12
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris
    Hôte
    • 62
    • 1
    Lapin
    Clonalité
    • 63
    Polyclonal
    Conjugué
    • 26
    • 7
    • 6
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MARK1 est non-conjugé
    Application
    • 49
    • 44
    • 33
    • 11
    • 8
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This MARK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 671-700 amino acids from the C-terminal region of human MARK1.
    Clone
    RB8547
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MARK1 Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Hezel, Gurumurthy, Granot, Swisa, Chu, Bailey, Dor, Bardeesy, Depinho: "Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms." dans: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2414-25, (2008) (PubMed).

  • Antigène
    MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
    Autre désignation
    MARK1 (MARK1 Produits)
    Synonymes
    anticorps MGC80341, anticorps MARK1, anticorps AW491150, anticorps B930025N23Rik, anticorps Emk3, anticorps Par-1c, anticorps mKIAA1477, anticorps mPar-1c, anticorps MARK, anticorps Par1c, anticorps MAP/microtubule affinity-regulating kinase 1 S homeolog, anticorps microtubule affinity regulating kinase 1, anticorps MAP/microtubule affinity-regulating kinase 1, anticorps MAP/microtubule affinity regulating kinase 1, anticorps mark1.S, anticorps MARK1, anticorps mark1, anticorps Mark1
    Sujet
    MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK
    Poids moléculaire
    89003
    ID gène
    4139
    NCBI Accession
    NP_061120
    UniProt
    Q9P0L2
    Pathways
    SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2
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