ADAMTS13 anticorps (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13) (AA 829-858)

Details for Product anti-ADAMTS13 Antibody No. ABIN391641
Antigène
  • ADAMTS13
  • ADAM-TS13
  • ADAMTS-13
  • C9orf8
  • VWFCP
  • vWF-CP
  • Gm710
  • ADAM metallopeptidase with thrombospondin type 1 motif 13
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13
  • ADAMTS13
  • Adamts13
  • adamts13
Épitope
AA 829-858, Center
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7
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2
2
2
2
2
1
1
1
1
1
Reactivité
Humain
91
19
17
Hôte
Lapin
70
15
4
2
Clonalité (Clone)
Polyclonal ()
Conjugué
Cet anticorp ADAMTS13 est non-conjugé
9
5
3
3
3
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3
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3
2
1
1
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1
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1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
52
32
15
13
8
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6
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2
2
1
Options
Immunogène This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 AA from the Central region of human ADAMTS13.
Clone RB18029
Isotype Ig Fraction
Specificité This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836~866 amino acids from the center region of human ADAMTS13.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Plasmids, Primers & others Plasmids, Primers & others ADAMTS13 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation ADAMTS13 (ADAMTS13 Antibody Extrait)
Sujet ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
Synonyms: von Willebrand factor-cleaving protease, vWF-cleaving protease, vWF-CP, A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAMTS-13, ADAM-TS 13, ADAM-TS13, ADAMTS13, C9orf8
Poids moléculaire 153604 DA
ID gène 11093
UniProt Q76LX8
Indications d'application WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption 6 months
Images (Fournisseur)
Western Blotting (WB) image for anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) (AA 829-858), (Center) antibody (ABIN391641) Western blot analysis of anti-ADAMTS13 Antibody (Center)(ABIN391641) in CEM cell line...
Immunohistochemistry (IHC) image for anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) (AA 829-858), (Center) antibody (ABIN391641) Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADAMTS13 Antibody (Ce...
Background publications Plaimauer, Fuhrmann, Mohr, Wernhart, Bruno, Ferrari, Konetschny, Antoine, Rieger, Scheiflinger: "Modulation of ADAMTS13 secretion and specific activity by a combination of common amino acid polymorphisms and a missense mutation." dans: Blood, Vol. 107, Issue 1, pp. 118-25, 2005 (PubMed).

Zheng, Chung, Takayama, Majerus, Sadler, Fujikawa: "Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura." dans: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 41059-63, 2001 (PubMed).

Levy, Nichols, Lian, Foroud, McClintick, McGee, Yang, Siemieniak, Stark, Gruppo, Sarode, Shurin, Chandrasekaran, Stabler, Sabio, Bouhassira, Upshaw, Ginsburg, Tsai: "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura." dans: Nature, Vol. 413, Issue 6855, pp. 488-94, 2001 (PubMed).

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