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BTK anticorps (AA 209-239)

BTK Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB03117 unconjugated
N° du produit ABIN392089
  • Antigène Voir toutes BTK Anticorps
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Épitope
    • 44
    • 22
    • 16
    • 15
    • 13
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 209-239
    Reactivité
    • 151
    • 90
    • 79
    • 14
    • 6
    • 4
    • 2
    Humain
    Hôte
    • 169
    • 13
    Lapin
    Clonalité
    • 144
    • 39
    Polyclonal
    Conjugué
    • 71
    • 15
    • 12
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Cet anticorp BTK est non-conjugé
    Application
    • 109
    • 67
    • 40
    • 40
    • 37
    • 27
    • 17
    • 17
    • 11
    • 10
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This BTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-239 amino acids from the Central region of human BTK.
    Clone
    RB03117
    Isotype
    Ig Fraction
    Top Product
    Discover our top product BTK Anticorps primaire
  • Indications d'application
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Autre désignation
    BTK (BTK Produits)
    Synonymes
    anticorps BTK, anticorps atk, anticorps bpk, anticorps xla, anticorps imd1, anticorps agmx1, anticorps psctk1, anticorps AGMX1, anticorps AT, anticorps ATK, anticorps BPK, anticorps IMD1, anticorps PSCTK1, anticorps XLA, anticorps AI528679, anticorps xid, anticorps Bruton tyrosine kinase, anticorps Bruton agammaglobulinemia tyrosine kinase, anticorps BTK, anticorps btk, anticorps Btk
    Sujet
    BTK plays a crucial role in B-cell ontogeny. This protein transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Defects in BTK are the cause of X-linked agammaglobulinemia type 1 (XLA). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis or fatal sepsis or meningitis within the first years of life.
    Poids moléculaire
    76281
    ID gène
    695
    NCBI Accession
    NP_000052
    UniProt
    Q06187
    Pathways
    Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling
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