PI4K2A anticorps (N-Term)

N° du produit ABIN392587

Détail du produit anti-PI4K2A anticorps

Antigène: PI4K2A (Phosphatidylinositol 4-Kinase Type 2 alpha (PI4K2A))

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PI4K2A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This PI4K2A (PI4K II) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PI4K2A (PI4K II).

Clone: RB1679

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:8000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur PI4K2A

Antigène: PI4K2A (Phosphatidylinositol 4-Kinase Type 2 alpha (PI4K2A))

Autre désignation: PI4K2A (PI4K II) (PI4K2A Produits)

Synonymes: anticorps pi4k2, anticorps pi4kii, anticorps PI4KII, anticorps PIK42A, anticorps RP11-548K23.6, anticorps Pi4k2, anticorps Pi4KII, anticorps pi4kII alpha, anticorps wu:fc84f05, anticorps zgc:63646, anticorps phosphatidylinositol 4-kinase type 2 alpha, anticorps phosphatidylinositol 4-kinase type 2 alpha L homeolog, anticorps PI4K2A, anticorps pi4k2a, anticorps pi4k2a.L, anticorps Pi4k2a

Sujet: Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs. PI4K II is activated by detergent and inhibited by adenosine. Overexpression of PI4KII in COS-7 cells increases synthesis of PtdIns4P. Some cells overexpressing PI4KII have scattered or no perinuclear Golgi. Knockdown of PI4KII by RNA interference (RNAi) does not disrupt the Golgi, and some cells show expanded Golgi. RNAi reduces the Golgi level of PtdIns4P and blocks the association between AP1 and the trans-Golgi network. PI4KII RNAi had little effect on intra-Golgi trafficking, but it inhibited export to plasma membrane export by 35 % . It has been proposed that PI4KII generates PtdIns4P-rich domains within the Golgi that specify docking of the AP1 coat machinery.

Poids moléculaire: 54022

ID gène: 55361

NCBI Accession: NP_060895

UniProt: Q9BTU6

Pathways: Inositol Metabolic Process, Synaptic Membrane