PIP5K1A anticorps (N-Term)

N° du produit ABIN392593

Détail du produit anti-PIP5K1A anticorps

Antigène: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Épitope: AA 19-50, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIP5K1A est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PIP5K1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human PIP5K1A.

Clone: RB01727

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PIP5K1A (ABIN392593)

Bolomini-Vittori, Montresor, Giagulli, Staunton, Rossi, Martinello, Constantin, Laudanna: "Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module." dans: Nature immunology, Vol. 10, Issue 2, pp. 185-94, (2009) (PubMed).

Zhu, Zeisel: "Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice." dans: Brain research. Molecular brain research, Vol. 134, Issue 2, pp. 239-55, (2005) (PubMed).

Détails sur PIP5K1A

Antigène: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Autre désignation: PIP5K1A (PIP5K1A Produits)

Synonymes: anticorps Pip5k1b, anticorps pip5k1c, anticorps PIP5K1A, anticorps pip5k1b, anticorps Pipk5a, anticorps Pipk5b, anticorps pip5k1a, anticorps zgc:110576, anticorps im:7140933, anticorps zgc:158838, anticorps phosphatidylinositol-4-phosphate 5-kinase type 1 alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b, anticorps PIP5K1A, anticorps Pip5k1a, anticorps pip5k1a.L, anticorps pip5k1a, anticorps pip5k1aa, anticorps pip5k1ab

Sujet: Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP(2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P(4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis.

Poids moléculaire: 62633

ID gène: 8394

NCBI Accession: NP_001129108, NP_001129109, NP_001129110, NP_003548

UniProt: Q99755

Pathways: Signalisation PI3K-Akt, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA