PTPN21 anticorps (AA 751-780)

N° du produit ABIN392838

Détail du produit anti-PTPN21 anticorps

Antigène: PTPN21 (Protein tyrosine Phosphatase, Non-Receptor Type 21 (PTPN21))

Épitope: AA 751-780

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN21 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PTPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human PTPD1.

Clone: RB0623-0624

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PTPN21 (ABIN392838)

Fox, Storey: "BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs." dans: Cancer research, Vol. 75, Issue 7, pp. 1345-55, (2015) (PubMed).

Détails sur PTPN21

Antigène: PTPN21 (Protein tyrosine Phosphatase, Non-Receptor Type 21 (PTPN21))

Autre désignation: PTPD1 (PTPN21 Produits)

Synonymes: anticorps PTPD1, anticorps PTPRL10, anticorps Ptp2E, anticorps protein tyrosine phosphatase, non-receptor type 21, anticorps PTPN21, anticorps Ptpn21

Sujet: PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.

Poids moléculaire: 133281

ID gène: 11099

NCBI Accession: NP_008970

UniProt: Q16825