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beta Amyloid anticorps (N-Term)

Abeta Reactivité: Humain, Souris WB, IF, EIA, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN401205
  • Antigène Voir toutes beta Amyloid (Abeta) Anticorps
    beta Amyloid (Abeta) (Amyloid beta (Abeta))
    Épitope
    • 18
    • 18
    • 13
    • 6
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-14, N-Term
    Reactivité
    • 72
    • 22
    • 15
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 42
    • 28
    • 3
    • 2
    Lapin
    Clonalité
    • 38
    • 31
    • 1
    Polyclonal
    Conjugué
    • 65
    • 5
    • 2
    • 1
    • 1
    • 1
    Cet anticorp beta Amyloid est non-conjugé
    Application
    • 54
    • 50
    • 30
    • 17
    • 15
    • 13
    • 9
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Séquence
    D-A-E-F-R-H-D-S-G-Y-E-V-H-H
    Réactivité croisée (Details)
    Species reactivity (tested):Human, Mouse.
    Purification
    Affinity Chromatography
    Immunogène
    Synthetic peptide corresponding to the amino terminus (1-14) of Human beta amyloid conjugated to KLH using maleimide.
    Isotype
    IgG
    Top Product
    Discover our top product Abeta Anticorps primaire
  • Indications d'application
    ELISA: 1/10,000. Western blot: 0.5-1.0 μg/mL. A 40-50 kD band consistent with a higher MW precursor isdetected in using whole tissue extracts from mouse brain. Immunofluorescence. Immunohistochemistry: We recommend the use of 4 % PFA for Paraffin embedded tissuesand 10 % Formalin for Frozen tissue for fixation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.55 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or(in aliquots) at-20 °C or below for longer .
  • Antigène
    beta Amyloid (Abeta) (Amyloid beta (Abeta))
    Autre désignation
    Amyloid beta (Abeta Produits)
    Synonymes
    anticorps AAA, anticorps ABETA, anticorps ABPP, anticorps AD1, anticorps APPI, anticorps CTFgamma, anticorps CVAP, anticorps PN-II, anticorps PN2, anticorps aaa, anticorps abeta, anticorps abpp, anticorps ad1, anticorps appi, anticorps ctfgamma, anticorps cvap, anticorps pn2, anticorps Abeta, anticorps Abpp, anticorps Adap, anticorps Ag, anticorps Cvap, anticorps E030013M08Rik, anticorps betaApp, anticorps amyloid beta precursor protein, anticorps amyloid beta (A4) precursor protein, anticorps APP, anticorps app, anticorps App
    Sujet
    Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.Synonyms: Amyloid beta peptide
    Pathways
    Inflammasome
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