Complement Component 6 (C-Term) anticorps

Détails pour le produit réf. ABIN461987
Antigène
Épitope
C-Term
17
10
4
3
3
2
2
2
1
Reactivité
Humain
72
9
7
Hôte
Souris
53
19
5
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
4
4
3
3
3
2
1
Application
ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
55
47
42
31
11
9
9
8
5
4
3
2
1
1
Options
Marque IHC-plus™
Immunogène Purified human C6.
Clone 056B-214-2-4-2
Isotype IgG1
Specificité Recognizes complement component 6 (C6) a 104 kD member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C terminus of the C5b alpha-chain, anchoring the molecule to the membrane and also binds complement component 7. This enables the formation of the C5b-7 precursor complex. C5b-7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection. Recognizes MAC.
Purification Protein A purified
Antigène
Autre désignation Complement C6
Sujet Name/Gene ID: C6

Synonyms: C6, Complement component C6, Complement C6, Complement component 6
ID gène 729
UniProt P13671
Indications d'application Approved: ELISA, Flo, IHC, IHC-P (10 μg/mL)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in  pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 10 μg/mL. Histology Positive Control Tissue: Kidney from post streptococcal glomerulonephritis patients.
Commentaires

Target Species of Antibody: Human

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Borate buffered saline, 0.09 % sodium azide. Sourced in Ascites.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing. Store undiluted.
Stock 4 °C,-20 °C
Stockage commentaire 4°C or -20°C, Avoid freeze-thaw cycles. Store undiluted.
Images (Fournisseur)
Image no. 1 for anti-Complement Component 6 (C-Term) antibody (ABIN461987) Human Liver (formalin-fixed, paraffin-embedded) stained with C6 antibody ABIN461987 a...
Image no. 2 for anti-Complement Component 6 (C-Term) antibody (ABIN461987) Human Placenta (formalin-fixed, paraffin-embedded) stained with C6 antibody ABIN46198...
Image no. 3 for anti-Complement Component 6 (C-Term) antibody (ABIN461987) Anti-C6 / Complement C6 antibody IHC of human liver. Immunohistochemistry of formalin...