PIAS1
Reactivité: Humain
WB, IHC, ICC, IP
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS containing 0.09 % (W/V) Sodium Azide as preservative.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Antigène
PIAS1
(Protein Inhibitor of Activated STAT, 1 (PIAS1))
anticorps 2900068C24Rik, anticorps Ddxbp1, anticorps GBP, anticorps DDXBP1, anticorps GU/RH-II, anticorps ZMIZ3, anticorps ddxbp1, anticorps gbp, anticorps pias, anticorps pias1-A, anticorps xPAIS1, anticorps xPIAS1, anticorps zmiz3, anticorps protein inhibitor of activated STAT 1, anticorps protein inhibitor of activated STAT, 1, anticorps protein inhibitor of activated STAT, 1a, anticorps protein inhibitor of activated STAT 1 L homeolog, anticorps PIAS1, anticorps Pias1, anticorps pias1a, anticorps pias1.L
Sujet
PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.Synonyms: DDXBP1, DEAD/H box-binding protein 1, E3 SUMO-protein ligase PIAS1, Gu-binding protein, PIAS-1, Protein inhibitor of activated STAT protein 1, RNA helicase II-binding protein