HACE1 anticorps (Internal Region)

N° du produit ABIN4889109

Détail du produit anti-HACE1 anticorps

Antigène: HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))

Épitope: Internal Region

Reactivité: Humain, Souris, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HACE1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Specificité: Reacts with human 102 kDa HACE1 protein

Réactivité croisée: Souris

Réactivité croisée (Details): Cross react with mouse and Xenopus protein due to sequence homology.

Purification: Purified (protein A)

Immunogène: Synthetic peptide derived from internal domain ofhuman HACE1 protein.

Information d'application

Indications d'application:

Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB: 1/1000 to 1/5000 IHC: 1/100 to 1/1000

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Concentration: 1 mg/mL

Buffer: Tris 0,1M, glycine 0,1M, sucrose 2 %

Stock: 4 °C/-20 °C

Stockage commentaire: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Date de péremption: 24 months

Détails sur HACE1

Antigène: HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))

Autre désignation: E3 Ubiquitin-Protein Ligase HACE1 (HACE1 Produits)

Synonymes: anticorps HACE1, anticorps 1700042J16Rik, anticorps A730034A22Rik, anticorps BC025474, anticorps HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1, anticorps HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog, anticorps HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1, anticorps HACE1, anticorps hace1, anticorps hace1.L, anticorps Hace1

Sujet: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

ID gène: 57531

UniProt: Q8IYU2