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ADD2 anticorps

ADD2 Reactivité: Humain, Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN4902845
  • Antigène Voir toutes ADD2 Anticorps
    ADD2 (Adducin 2 (Beta) (ADD2))
    Reactivité
    • 29
    • 24
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 42
    • 2
    Lapin
    Clonalité
    • 44
    Polyclonal
    Conjugué
    • 23
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ADD2 est non-conjugé
    Application
    • 36
    • 13
    • 13
    • 11
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Attributs du produit
    Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
    Purification
    Affinity purification
    Immunogène
    Recombinant protein of human ADD2.
    Isotype
    IgG
    Top Product
    Discover our top product ADD2 Anticorps primaire
  • Indications d'application
    WB 1:1000-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C.
  • Antigène
    ADD2 (Adducin 2 (Beta) (ADD2))
    Autre désignation
    ADD2 (ADD2 Produits)
    Synonymes
    anticorps si:dkey-202n14.5, anticorps ADDB, anticorps 2900072M03Rik, anticorps add97, anticorps beta-ADD, anticorps adducin 2, anticorps adducin 2 (beta), anticorps ADD2, anticorps add2, anticorps Add2
    ID gène
    119
    UniProt
    P35612
    Pathways
    Regulation of Actin Filament Polymerization
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