ADD2 anticorps
-
- Antigène Voir toutes ADD2 Anticorps
- ADD2 (Adducin 2 (Beta) (ADD2))
-
Reactivité
- Humain, Souris
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp ADD2 est non-conjugé
-
Application
- Western Blotting (WB)
- Attributs du produit
- Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
- Purification
- Affinity purification
- Immunogène
- Recombinant protein of human ADD2.
- Isotype
- IgG
- Top Product
- Discover our top product ADD2 Anticorps primaire
-
-
- Indications d'application
- WB 1:1000-1:2000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C.
-
- Antigène
- ADD2 (Adducin 2 (Beta) (ADD2))
- Autre désignation
- ADD2 (ADD2 Produits)
- Synonymes
- anticorps si:dkey-202n14.5, anticorps ADDB, anticorps 2900072M03Rik, anticorps add97, anticorps beta-ADD, anticorps adducin 2, anticorps adducin 2 (beta), anticorps ADD2, anticorps add2, anticorps Add2
- ID gène
- 119
- UniProt
- P35612
- Pathways
- Regulation of Actin Filament Polymerization
-